GEORGE E. GIFFORD, JR.

Botanic Remedies in Colonial Massachusetts, 1620–1820 *

WHEN the Mayflower landed on the Massachusetts coast in 1620, on board was a botanical book belonging to Elder Brewster, A Brief Epitomy of the New Herbal etc., first set forth in ye Dutch tongue; by Rembert Dodoens.1 No doubt this was referred to by Dr. Samuel Fuller, the ship’s physician, who was described as “well qualified in his profession.”2 It is not known if Fuller had a collegiate education, but all practitioners were familiar, to some degree, with folk medicine—the traditional pharmacopoeia.

English medicine in the early 1600’s was essentially medieval and credulous with no clear distinction between the natural, the supernatural, and the occult.3 William Harvey, having demonstrated the circulation of the blood in 1628 in a “modern” manner, thereupon concluded that the origins of the heart’s motion lay “in innate heat, which was ascribed to the soul or spirit of the blood; and this in turn was described as ‘identical with the essence of the stars.’”4 But the old medicine was slowly giving way to a new system.

Galenic theories of humors and herbal polypharmacy had been attacked by Paracelsus, who advocated chemical treatments and the concept that there were distinct diseases, each with its own causes and cures. Both Galen and Paracelsus had clear views as to the use of herbs and botanic remedies. In the Galenic theory, illness was ascribed to imbalance or impurities in the four major fluids or humors, from which was deduced a need for ridding the body of such humors by various means—bleeding, purging, sweating, and the like. Herbs, used as cathartics and sudorifics (diaphoretics), were important. Every vegetable was classified according to its properties in relation to the four humors, and to four varying degrees. For example, chicory was classified as cold in the fourth degree and pepper as hot in the fourth degree, whereas endive was cold and dry in the second degree. Galen’s work on herbs, De simplicibus, has been maintained etymologically by the old medical word “simple,” meaning an herb; and, similarly, by the word “galenical,” meaning a decoction or infusion of herbs and roots.5

Paracelsus reclaimed the ancient “doctrine of signatures” to explain which plant would “cure” a specific disease.6 According to this teleological and allegorical cryptography, plants and minerals were marked by some natural sign or symbol indicating the particular medicinal use for which they could be employed. Regarding Hypericum or Saint-John’s-wort, Paracelsus wrotc,”I have oft-times declared, how by the outward shapes and qualities of things we may know their inward virtues, which God hath put in them for the good of man. So, in St. John’s wort, we may take notice of the form of the leaves and flowers, the porosity of the leaves, the veins. 1. The porosities or holes in the leaves, signifie to us, that this herb helps both inward and outward holes or cuts in the skin. ... 2. The flowers of Saint John’s wort, when they are purified, they are like blood; which teacheth us, that this herb is good for wounds, to close them and fill them up.”7

60. Plate showing scorpionlike herbs, from Iohannis Baptista Porta, Phytognomonica (1650). Courtesy Boston Medical Library.

61. Digitalis purpurea, or foxglove, from Rembert Dodoens, Herbal, translated by Henry Lyte (London, 1578). In the accompanying text Dodoens notes that digitalis is useful chiefly for relieving obstructions of the four humors and, especially, for stimulating the flow of phlegm. The plant was not native to colonial New England. Courtesy Boston Medical Library.

62. A page from the letter of “Medical Directions” sent by Dr. Edward Stafford of London to Governor John Winthrop in Boston, 6 May 1643. Courtesy Boston Medical Library.

63. Jewelweed (above) and skunk cabbage (facing page), woodcuts from John Josselyn’s New-Englands Rarities Discovered (London, 1672). Compare with figure 70. Courtesy Boston Medical Library.

64. Page from the account book of Bartholomew Browne, apothecary in Salem, 1698–1704. Courtesy Essex Institute, Salem, Massachusetts.

65. Request of surgeon Will Locke for drugs from the Governor and Council of Massachusetts, 30 May 1676. The letter is transcribed in Early History of Massachusetts (Boston: Massachusetts Historical Society, 1869). Courtesy Massachusetts State Archives.

66. Title page of the Boston edition of Nicholas Culpeper’s English Physician, 1708, the first medical book published in colonial America. Courtesy Boston Medical Library.

According to his doctrine, yellow flowers such as saffron, yellow celandine, and turmeric were used for jaundice. The scorpion-grass, the old name for the forget-me-not, was efficacious for the bite of the scorpion, because the seed pod of the plant resembled the nodular tail of a scorpion; the thistle, for a “stitch in the side”; and walnut meats, because of their rough resemblance to the convolutions of the brain, would afford a natural cure for all cranial ailments. The doctrine also applied to products and minerals. The spotted skin of the lizard was a remedy for malignant tumors, the skin resembling secondary nodules; toads were used for treating smallpox, syphilis, and diseases exhibiting wartlike eruptions; bloodstone was taken as a cure for hemorrhage, and topaz as a cure for jaundice. Closely allied to the doctrine of signatures was the “sympathy cure”: “Madde Dogge livers for the bite of mad dogs,” rattlesnake livers for the bite of the rattlesnake, bear grease for baldness, and powdered mummy for prolonging life.

The Paracelsian doctrine of signatures was translated therapeutically into “curing by the assimulate,” “assimulate” being the old English word for similar. This was in contrast to the Galenic theory of “contraries cured by contraries”—for example, giving milk (being white) to clear the blood of black humors.8

Both Galenic and Paracelsian theories were espoused in the herbals that hallmarked the medical renaissance. The herbals did not confine themselves to herbs but were a “Pharmacopoeia for the poor which described for the benefit of the reader, useful substances from each of the three natural kingdoms.”9 Rembert Dodoens (1517–1585) studied medicine in France, Italy, and Germany, and in 1582 was invited to a professorship of medicine at Leyden.10 His work, Stirpium historiae pomtades sex (1583), was the basis of the most popular English herbal, The Herball or Generall Historie of Plants (1597), by John Gerard, a barber-surgeon.

The influence of Gerard’s Herball or “Gerrits Herbal” and the intermingling of Paracelsian and Galenic botanic remedies is evident in a 1643 letter of Dr. Stafford of London to the younger Governor Winthrop of Connecticut.11 The letter contains “receipts” to cure twenty disorders: madness, falling sickness (epilepsy), “for ye mother,” “Lethergie” or vertigo, disease of the bladder, stopping of urine, or stone, bloodie flux (dysentery), “janders” (jaundice), pain, broken bone, plague, smallpox, poison, fevers, old sores, burning with gunpowder, sore breasts, boils, green wound, king’s evil (tuberculosis). The botanic remedies given are twenty-four: Hypericum (Saint-John’s-wort), spurge, black hellebore, cinquefoil, bryony, “four great cold seeds,” aaron, oak bark, maidenhair, fennel, parsley, rhubarb, saffron, elm, witch hazel, elder, sempervine, foxglove, clown’s wort, jalap, scammony, snakeroot, contrayerva, and tacka-mahacha (tamarack).

The Galenic concept of humors is seen when Stafford prescribes for inflammation of the bladder or “heate of the urine.” He prescribes a “cold” remedy for the heat, recommending one of “The four great cold seeds”: from the cucumber, the gourd, the watermelon, or the melon, all fruits which are watery and “cool.” The expression “cool as a cucumber” is a Galenic holdover.12

The Paracelsian doctrine of signatures can be seen in the use of Saint-John’s-wort for burns or wounds, as described earlier by Paracelsus. Similarly, spurge was used as a purge (the leaves upward, purge; the leaves downward, vomit); saffron, the yellow flower parts of crocuses, for jaundice; toads, for tuberculosis (secondary skin lesions); and flexible twigs of witch hazel or elm for broken bones. The “law of sympathy” is demonstrated by wearing a wildcat skin for pains in the limbs and breasts.

The English herbal tradition continued with John Parkinson’s Theatrum Botanicum: The Theatre of plants, or an Herball of a large extent (London, 1640).13 In 1649 and 1653 Nicholas Culpeper published A Physical Directory or a translation of the London Dispensatory made by the College of Physicians in London. Culpeper “indulged in a vast amount of scurrilous raillery at the expense of the London Pharmacopoeia of 1618 and 1650.”14 The London Pharmacopoeia of 1618 contained 1960 remedies, of which 1028 were simples, 91 animals, and 271 vegetables.

What herbs did the early settlers of Massachusetts use? Although the Pilgrims had a copy of Dodoens’s Herbal, their only remedies would have been the garden herbs they brought with them or the medical plants that the Indians shared with them. The English women were experienced herb gatherers, and they had a lore that extended back to very early times.15 “Kitchen gardens were laid out in accordance with homeland plans. Within these gardens some of the popular medicinal herbs of the Old World were planted. Josselyn’s Account of New England (1692), ‘Of such Garden herbs (amongst us) as do thrive there, and of such as do not,’ contained about fifteen herbs which were used in contemporary English medicine, e.g., burnet, (Sanguisorba minor), groundivy (Nepetaglechoma), and feverfew (Chrysanthemum parthenium).”16

English herbs were best for English bodies: this had been the theory advanced in Timothy Bright’s A Treatise, wherein is declared the sufficiencie of English medicines, for cure of all Diseases, cured with medicines, whereunto is added a collection of medicines growing (for the most part) within our English Climate, approved and experimented against the jaundice, dropsie, stone, falling sickness, pestilence.17 But there was another concept dating back to Paracelsus, which stated that in the country where a disease arises, there nature produces the means to overcome it. This concept recurs in many herbals. In 1664, Robert Turner summed up the theory: “For what climate so ever is subject to any particular Disease, in the same Place there grows a Cure.”18 This explains why rattlesnake plantain, which grows near rattlesnake dens, is an antidote for the rattlesnake bite, and why docks grow near stinging nettles, and jewel weed near poison ivy. These are cures in situ. The idea was surely reinforced after 1640 with the introduction of cinchona bark for the treatment of malaria. It was becoming clear that new and powerful medicines were to be found in the New World flora.19

The theory of signatures also played a part in the medical theory of many American Indian tribes.20 Take, for example, the Seneca snakeroot (Polygala senega): “It seems that the plant had long been used by the Seneca tribe of Indians as a specific in cases of poisoning by the bite of a rattlesnake. They had inferred this from a supposed resemblance between the root of the plant and the rattle of the snake.”21

The settlers benefited from the skill of native healers who understood the medicinal value of many indigenous animal and vegetable products.22 Their simple remedies were quite unlike the complicated nostrums and electuaries of Europe which sometimes contained up to eighty ingredients. Such an uncomplicated approach encouraged the settlers to establish an independent tradition of prescribing a specific remedy for a specific ailment. It also caused them to gradually shift from relying on the European schoolmen to depending on the simples and specifics of the old wives, Indians, and ministers. The contributions of the Indians can be gauged by the fact that of the fifty-six Indian drugs holding recognition in 1925, thirty of them had been used by the Indians of New England.23 “Native American medicine was not, therefore, in conflict with the technique introduced by the first practitioners. Instead, there was a favorable exchange of ideas, a factor which obscures the derivation of many of the colonial remedies.”24 As early as 1588, Hariot reported that sassafras was “of most rare vertues in physick for the cure of many diseases,” that tobacco “purgeth superfluous fleame and other gross humors,” and that “sweet gummes of divers kinds” were also used.25

In 1602, Bartholomew Gosnold and his crew landed in Massachusetts to load the first cargo of New England exports, which consisted of the bark and the pith of the sassafras tree. The same year Sir Walter Raleigh returned from Cape Fear with a cargo of timber, sassafras, china root, benjamin (spicebush), sarsaparilla, cassis lignea, and an unknown “strong bark.” Sassafras was exported throughout the colonial period; in 1770 alone, England imported nearly seventy-seven tons of it.26 Peter Kalm, in his Travels, relates that in earlier days the Englishmen had been fond of drinking sassafras tea, but when it became common knowledge that such a decoction was a treatment for syphilis, they stopped for fear that others would think them diseased.27 The collection, cultivation, and exportation of plant drugs such as ipecac, Virginia snakeroot, and ginseng were of considerable economic significance in the colonies.28

The first record of Indian herbal medicine was by John Josselyn, an English botanist, explorer, and practitioner of medicine. Josselyn came to New England in 1638, stayed for eighteen months, returned in 1663, and remained eight years. In 1672 he published his New-Englands Rarities Discovered: In Birds, Beasts, Fishes, Serpents and Plants of that Country. Together with the Physical and Chyrurgical Remedies wherewith the Natives Constantly use to Cure their Distempers, Wounds, and Sores. Josselyn describes the diseases to which the Indians were subject and he relates the plant remedies they used.29 Among them was the white hellebore: “The Indians cure their wounds with it, anointing the Wound first with Raccoons greese, or Wild-Cats greese, and strewing upon it the powder of the roots; and for Aches they sacrifice the grieved part, and annoint it with the aforesaid Oyls, then strew upon it the powder: The powder of the Root put into a hollow Tooth, is good for the Tooth-ach: The root sliced thin and boyled in Vinegar, is very good against Herpes Milliaris.” Josselyn reported that “the bark of Birch is used by the Indians for bruised Wounds and Cuts, boyled very tender, and stampt betwixt two stones to a Plaister, and the decoction thereof poured into the wound; And also to fetch the Fire out of Burns and Scalds.”30 Of one of the New World’s most famous flora he wrote that “the virtues of Tobacco are these, it helps digestion, the Gout, the Tooth-ach, prevents infection by scents, it heats the cold, and cools them that sweat, feedeth the hungry, spent spirit restoreth, purgeth the stomach, killeth nits and lice. . . .”31

The following excerpt from Josselyn is an example of how plant lore was transmitted to the colonists: “One Christopher Luxe: a fisherman having burnt his Knee Pan, was healed again by an Indian Webb, or wife (for so they call those Women that have husbands;) She first made a strong decoction of Alder bark, with which she took out the fire by Imbrocation, or letting of it drop upon the sore, which would smoak notably with it; then she Playstered it with the Bark of Board Pine, or Hemlock Tree, boyled soft and stampt betwixt two stones, till it was as thin as brown Paper, and of the same Colour, she annointed the Playster with Soyles Oyl and the Sore likewise, then she laid it on warm, and sometimes she made use of the bark of the Larch Tree.”32

Peter Kalm (1715–1779) was a Swedish naturalist, a student of Linnaeus, who visited the colonies in 1748 and remained for two and a half years. He collected plant specimens and observed social conditions in colonial America from Philadelphia north to Quebec. In his observations on life in colonial America, he described the remedies being used by the colonists, and he specifically remarked on remedies learned from the Indians as well as remedies that the colonists used when they were unable to find European plants and were forced to substitute native plants. One remedy which the colonists used as a substitute for an unavailable plant was the root of the tulip tree; Kalm said that “many people believe its roots to be as efficacious against the fever as Jesuit Bark.”33 Jesuit missionaries in South America in 1632 had learned of the value of the bark of the cinchona tree, thus its appellation, “Jesuit Bark.”

Another Indian remedy described by Kalm was the use of the seed capsules of the Virginia Anemone for the ache occasioned by a hollow tooth. The method consisted of rubbing the seed capsules so that they looked like cotton, soaking them in strong brandy, and placing them in the tooth.34 Another remedy was told to Peter Kalm by John Bartram, who heard of it from Conrad Weisser, an interpreter of the Indian language. He said that “he was once among a company of Indians, one of which had been stung by a rattlesnake, the savages gave him over; but he boiled the Collinsonia (Blue-eyed Mary) and made the poor wretch drink the water, from which he happily recovered.” He also related that, in other parts of the country, the plant is called horseweed, illustrating the practice of different sections of the country having different names for the same plant.35 In one of his papers on natural history, Kalm published, in 1750, an account of “Lobelia as a sure remedy against venereal disease.”36

The role of the minister in the practice of medicine in colonial Massachusetts was of great importance. Two ministers who specifically concerned themselves with botanic remedies were the Reverend Cotton Mather and the Reverend Thomas Harwood. Mather was most interested in Indian medicine. He was convinced that God had placed remedies in each part of the world where they were appropriate, and since the Indians had dwelt long in America, they might well have been the first to find the blessings peculiar to their continent. In 1723 he wrote “that for our physick, as well as for our food, Every Creature of God is good, and nothing is to be refused, if it be received with Thanksgiving.” In a letter, Mather discussed unique American plants with which “our Indians do cures many times which are truly stupendous.”37

67. Title page of Boston edition of Nicholas Culpeper’s Pharmacopoeia Londinensis, 1720, widely used in colonial Massachusetts. Courtesy Boston Medical Library.

68. Inscriptions in Rachel Martin’s copy of Culpeper’s Pharmacopoeia Londinensis, the title page of which appears in figure 67. This book was popular with colonial housewives. Courtesy Boston Medical Library.

69. First page of Manasseh Cutler’s Account of Some of the Vegetable Productions Naturally Growing in this Part of America (Boston, 1785). Courtesy George E. Gifford, Jr.

70. Plate of skunk cabbage from Jacob Bigelow, American Medical Botany (Boston, 1818). Compare with figure 63. Courtesy Boston Medical Library.

Mather reported an Indian tea of Fabiana efficacious for cancers and fevers. Other Indian cures included partridgeberry, as a powerful diuretic which would cure dropsy; “throatweed,” helpful in sore throats; “cranesbill,” which, when brewed into a tea, would heal lues venerea in two weeks; and “Bleeding root,” which could cure jaundice within six days.38 His Angel of Bethesda, meant to serve as a “family medical manual,” was addressed to physicians and the public. It has been suggested that it was never published because it fell between the schools of “professional and popular appeal.”39

The Reverend Thomas Harwood, Lecturer at the King’s Chapel in Boston and Licentiate of the Royal College of Physicians in London, published his Electuarium novum Alexipharmacum, Or, A new cordial, alexiterial and restorative electuary; which may serve for a succedaneum to the grand theriaca andromachi. The Theriaca examined, with reasons humbly offered why the troches should be ejected, as well as a great number of the rest of the ingredients. A new correlation of theriaca most humbly proposed . . . (Boston, 1732).40 Theriaca was considered an antidote to poison, compounded of many drugs and honey.

Two documents, the Account Book of Bartholomew Browne41 in the Essex Institute in Salem, Massachusetts, and the Drug List of King Philip’s War42 in the Archives of the State House in Boston, Massachusetts, when placed in juxtaposition, present an excellent “point-counterpoint” of medical practice in the colonies. The drug list describes medical practice as seen by a newly arrived “chirurgeon,” whereas the Browne account book is a unique document, for it is the first record of business transactions in pharmacy in New England.

Bartholomew Browne was a “pharmaceutical-chemist” who practiced as a pharmacist and occasionally made visits as a physician. He was one of three apothecaries in Salem, where there were four physicians, at least three of whom were his customers. Careful perusal of his account book reveals that Browne’s “medical armamentarium” was uniquely chemical in nature. During the period of June 1698 through December 1704, he dispensed no less than 335 pots of “alb Samech” (white Samech). It is not remarkable that there would be extensive use of tartar as a cure for many ills; most of the medical texts from Europe advocated its use. (It was recommended by Salmon, Paracelsus, Boerhaave, and others.) However, in addition to white Samech, Bartholomew Browne prepared a unique series of herb preparations with tartar which are not to be found in any of the standard texts or pharmacopoeias of the day. Browne sold 326 pots of an unidentified “Elixir Proprietas.” (According to Salmon,43 Elixir Proprietas was composed of aloes, myrrh, and saffron prepared with a “Tartarized Spirit of Wine.”) Other dispensations of Browne included a cordial powder (to strengthen and comfort all the natural, vital, and animal powers), preparations to dispel worms, emetics, and other less-frequently-prescribed medicines.

Dr. William Locke arrived in Boston from England in 1675 and apparently lost no time in offering his services to the colony at the outbreak of King Philip’s War. Locke was in Hadley, Massachusetts, caring for the wounded and ill soldiers, when he wrote an urgent letter to Mr. Rawson, Secretary of the Massachusetts Bay Colony, stating that this was his second letter requesting urgently needed supplies. It is assumed that the order of drugs was to be sent from England, because the items requested seem more complex than could be compounded in the colonies. Practically all the items requested are to be found in the London Pharmacopoeia of 1650; one medicine requested contained no less than fifty ingredients. Locke appealed for opiates, stimulants, cathartics, plasters, and “old linnen as much as you can get” for bandages. By comparing the newcomer Dr. Locke’s drug list to the established Bartholomew Browne’s list of dispensations, we see the beginning of independence from the standard European pharmacopoeia.

Books giving advice for self-treatment as well as for the cultivation of herbs were much cherished and used by the English emigrants. The most important of these was Gervase Markham’s The English Housewife Containing The inward and outward Vertues which ought to be in a Compleat Woman as her skill in Physicke, Chirurgery, Cookery, Extraction of Oyles Banqueting stuff, Ordering of Great Feasts and The English Husbandman (1613).44 Another was Nicholas Culpeper’s The English Physician (London, 1652), which was reprinted again and again and used for more than a century.45 In 1708, a work of the same title and attributed to Culpeper was published in Boston, a tribute to the work’s popularity. The work was “obviously intended for the layman and presented what purported to be Culpeper’s ‘choicest secrets.’ . . . The remedies were domestic and largely, though not entirely, herbal. Thus, for ‘Pains and Aches in the Back, Hip, Sides, or any part of the Body,’ one remedy was a concoction of Syrup of Poppy, Syrup of Betony, and Waters of Bugloss and sage. Another included the following directions: ‘Take the Gall of an heifer for a Man; the Gall of a Steer for a Woman, Brandy, or each a like Quantity, boyl them together ‘till it begin to be clammy, and before the Fire with a warm hand strongly bathe the Party Morning and Evenings, ’till he be whole.’”46

The second American medical book was a reprint of Nicholas Culpeper’s Pharmacopoeia Londinensis or The London Dispensatory, published in Boston in 1720. “This is a very significant book; not only was it the first full length medical work published in the colonies but was also the first work of a pharmacopoeial or dispensatory nature.”47 The work is indebted to the “old” pharmacopoeia of 1618, and the “new” pharmacopoeia of 1650. The “Catalogue of Simples” is from the 1650 edition. Roots are classified as “hot” in four degrees, “temperate,” “cold” in three degrees, “dry” in four degrees, and “moist.” Then the roots were classified by the parts of the body they affected; those that heated the head, the neck, and the throat, the stomach, and the bowels. Next they were classified by their “properties,” e.g., those that mollified, glutinated, and purged.

According to Sonnedecker, the book apparently attained no professional status. However, these books must have been treasured by the colonial housewife. “A London edition of 1667, for example (in the Boston Medical Library), bears a fly-leaf notation that the book was given to Grace Greenleaf ‘by her honoured Mother ... in the year 1764.’ The same book noted that Grace gave it to her sister Elizabeth two years later. A copy of the Boston edition of 1720 (in the same library) bears the notation, ‘Rachel Martin, Her Book, Given Her by Her Mother Jest before her Deth, March 13 th Day 1765.’”48

Later in the century William Buchan’s Domestic Medicine (London, 1769) was so popular that it was published at least fifteen times in the colonies and the new United States between 1771 and 1799, and many times afterward.49 A New Haven edition published in 1816 was called Every man his Own Doctor; or a Treatise on the Prevention and Cure of Diseases, by Regimen and Simple Medicines. To Which is Added, a Treatise on the Materia Medica; in which the Medicinal Qualities of Indigenous Plants Are Given and Adapted to Common Practice. With an Appendix, Containing a Complete Treatise on the Art of Farriery. With Directions to the Purchasers of Horses; and Practical Receipts for the Cure of Distempers Incident to Horses, Cattle, Sheep, and Swine—to all which are added, a Choice Collection of Receipts, Useful in Every Branch of Domestic Life—Making it All a Complete Family Directory.50

The self-help tradition had an American exponent in New England’s own Dr. Samuel Stearns (1741–1809).51 Born in Bolton, Massachusetts, he began the practice of medicine at the age of thirty years, in Paxton, Massachusetts. He was a prolific and expansive writer for The North-American’s Almanack being the Gentlemens and Ladies Diary for the year of Christian Aera, 1771. . . . Also, a variety of excellent medicines, extracted from authors, shewing an easy way of curing diseases, with an account of the wonderful operations of the Bite of a Mad Dog on the Human Body, and directions for working the cure of the same, &c, &c. Accused of being a Tory, Stearns escaped from Paxton and took the Oath of Allegiance to the King before the mayor of New York. He practiced in New York and Long Island. After the war, he returned to Paxton and was jailed in Worcester for three years. He then moved to Brattleboro, Vermont, and Quebec; in 1790, he went to England and Paris. On 2 October 1790 Stearns obtained a Doctor of Laws degree from Aberdeen University. Of this degree it was written, “In America it is not generally known that for twelve pounds two shillings and six pence, sterling, any creature can obtain in the University of Aberdeen and at St. Andrews a diploma, which will dignify the possessor with a Doctor’s Degree in Divinity, Law or Physic. . . .”52

After returning to the United States, he continued a peripatetic medical career in Connecticut, Vermont, and Rhode Island, continuing to write and practice. His magnum opus was his book of 1801, The American Herbal, or Materia Medica, Wherein, the Virtues of the Mineral, vegetable, and animal productions of North and South America are laid open, so far as They Are Known: and Their uses in the practice of physic and surgery exhibited. In the Preface to the American Herbal, Stearns observed that medical books, having been written at various periods, “frequently gave different accounts concerning the virtues, operations and effects of medicines, upon the human body; the description of diseases, and the methods of prescribing remedies for their ‘cure,’ that there was no established rule ‘in America’ for a guide to the apothecaries in compounding their medicines,” and “that the methods of instruction were likewise different, amongst the different teachers of the healing art.”53 Also in the Preface he gives a list of books that “ought to be spread through all the regions of the medical world, that the mind of our practitioners may be illuminated, and their practice regulated.”54 The list includes: Pharmacopoeia Londinensis; Lewis’s Materia Medica, in quarto; Cullen’s Nosology; Motherby’s Medical Dictionary; London Practice of Physic; Practice of the London Hospitals; Wallis’s Works; Transactions of the College of Physicians in Philadelphia; Rush’s Medical Enquiries; Bartram’s Botany; Dictionary of Arts and Sciences.

John C. L. Clark’s evaluation of Stearns’s book is ambivalent: “The American Herbal ... is confined to medicines indigenous to America. I think you would call him a ready writer rather than a thinker, an organizer rather than an observer. It is greatly to his credit that he organized the idea of compiling a dispensatory for the Colonies, and that he published his ‘Herbal’ of indigenous drugs; but he did not use well the material which he says he studied.”55 With Stearns, the United States had produced its own Nicholas Culpeper, a “doctor” writing in the time-honored self-help tradition.

Also within this self-help tradition was Methodist theologian John Wesley’s Primitive Physic (London, 1747) which was reprinted many times.56 As an educated reformer, Wesley’s concern was to provide a book of safe, effective remedies that were available to the common man. Wesley himself was Oxford-educated, but his volume was in rebellion against the men of science, especially those who practiced physic.

To introduce his book, Wesley hearkened back to the “original sin” concept; he maintained that God provided illness and pestilence as part of the punishment for the sinfulness of man. Further, he felt that God, in his goodness, provided the cures for these diseases in a place nearby. Wesley’s concepts closely paralleled the old doctrine of signatures. For example, in describing a village cursed with sores of the mouth, he related that one of the villagers was walking in a forest when a drop of the tar from the pine tree fell onto his sore mouth. Immediately, he was relieved and was able to tell others of the “cure.”

Wesley said that for these simple, “primitive remedies” to be effective, one must lead a simple life: Fear God, get plenty of exercise, keep clean, and exercise temperance in all things. He allowed that one might consult a “God-fearing” physician if one did not know the nature of an illness, but implied that this should occur only rarely. Most of Wesley’s remedies remind one of the remedies from the old herbals and self-help books, as well as the folklore and Indian remedies. He even pointed out that the Indians were seldom ill and said this was due to their “continual exercise” and “universal temperance.” Wesley further states that if the Indians did become ill, the fathers told the children what remedy to apply. The Reverend Wesley stated that the practice of physic became complex and abstruse so that the physicians could become wealthy and powerful. His book, originally published in London in 1747, was printed in America at least seven times between 1764 and 1795. This book was another that facilitated the separation of American dependence on European medical theory and drugs.

Early colonial botanic remedies were, then, composites of several distinct traditions intermixing, tempered by the American environment with its own flora. There was the “kitchen physic” that grew out of the leech and “good woman” tradition; there was the Indian materia medica; there was the flood of self-help books by authors such as Culpeper, Buchan, and Wesley; there was the “Angelic Conjunction” or the physician-minister who suffused the decoction with theological endorsement; and there were the official remedies based on the English pharmacopoeias, which were, in turn, based on the dying Galenic theories and the new theories of Sydenham, who advocated specific cures for specific diseases. These varying traditions were fused by a long period of empirical, largely self-administered, and, consequently, independent evaluation.

One of the most significant contributions to colonial botanic remedies was made by the Reverend Manasseh Cutler.57 Cutler (1742–1823), of Hamilton, Massachusetts, was born in Killingly, Connecticut. Graduated from Yale University in 1765, he practiced law, then studied theology. In 1779, he wrote that money had depreciated so much that he had spent a considerable part of his estate in support of his family and so was “driven to the practice of physic.”58 He read medicine assiduously, studied anatomy, prepared medicines, and attended the sick in addition to his usual pastoral duties. One can speculate that his botanical interest may have arisen from his study of physic, for it was in 1780 that he first mentioned his interest in plants; he borrowed Catesby from the Harvard Library. In 1781, Cutler wrote to Harvard asking to borrow Dr. Hill’s Natural History. (John Hill [1716–1775] issued a huge botanical work of twenty-six volumes, The Vegetable System, with 1600 copperplate engravings, from from 1759 through 1775.)59

Withering published his Botanical Arrangement of British Plants in 1776 and that must have been one of the volumes that Cutler studied when he read physic and botany.60 In 1785 Manasseh Cutler presented his paper “An Account of Some of the Vegetable Productions naturally growing in this Part of America, botanically arranged” to the American Academy of Arts and Sciences.61 The American Academy of Arts and Sciences was organized by a group of scholars in and around Boston who felt the need for a “learned society.” Its first meeting was on 31 January 1781, and Manasseh Cutler records the meeting and says that he “had the honor of being elected a member.”62 The Academy hoped to attract papers on basic science and “promote useful knowledge.”

In presenting his paper to the Academy, Cutler said that he had arranged it according to the Linnaean system, that the “medical and economic uses which are mentioned, are inserted from the best private information that could be obtained, or selected from good authorities; many of them, in particular, from a late ingenious and useful publication by William Withering, m.d., entitled, ‘The Botanical arrangement of British Plants.’”63 Dr. Cutler included only plants that were growing within the compass of a few miles, all in New England. He decries the lack of any botanical publication about the plants of his area, and says it may be due to the fact that botany “has never been taught in any of our colleges.” Further, he says, “the grossest mistakes have been made in the application of English names of European plants, to those in America.”

In all, the Reverend Cutler entered 328 different species; of that number he had entries describing medical uses for eighty-five of them, some having more than one medicinal effect. In his entries regarding medical effects, he refers most often to Dr. Withering, twenty-three times. Cutler also records remedies used by the Indians, and refers to other sources, namely, Hill, Linnaeus, Boerhaave, and Cullen. The reader may further assume that some of the remedies arose from his own experience as a physician.

One of the plants Cutler described was Salix: “The white Willow. The Red Willow. The Rose Willow. The Dogwood. The Osier. An account is given in Transactions of the Royal Society (vol. I, iii, p. 195) by the Rev. Mr. Stone, of the great efficacy of white willow bark in curing intermittent fevers. He gathered the bark in summer, when it was full of sap; dried it by a gentle heat, and gave a dram of it powdered, every four hours between the fits. In a few obstinate cases he mixed it with one fifth of Peruvian bark. Some judicious physicians, here, have made trial of the bark of the white willow, and recommend it as a valuable substitute for the Peruvian bark. They have used principally the bark of the roots.”64

Among Cutler’s many correspondents was Dr. Jonathan Stokes, a botanist of note and a contemporary of Withering whom he had assisted in preparing his work. Stokes himself authored a botanical materia medica published in London in 1812. Dr. Cutler also corresponded with Benjamin Smith Barton, Professor of Natural History and Botany in the College of Philadelphia, and author of many works on botany and materia medica.65 Dr. Henry M. Muhlenberg, a minister from Pennsylvania who was especially distinguished in the study of botany, wrote to Dr. Cutler asking for his paper on the plants of Massachusetts. The two exchanged scientific information and botanical specimens.66 Another correspondent was Professor C. S. Rafinesque; he studied botany and published Medical Flora (2 v., 1828.67 Cutler was in the minister-physician tradition, or, as Cotton Mather called it, the “Angelic Conjunction.” His correspondent, H. Muhlenberg, too, was in this fraternity. Two of his other correspondents, Barton and Rafinesque, were physicians beginning to take note of the indigenous American materia medica, but Cutler’s work was the first serious study of New England plants and their medical uses.

It was inevitable that an American pharmacopoeia or Materia Medica would be compiled with a list of native botanical remedies by the regular medical practitioners rather than by the “clergyman-physician” Cutler or that American original, “Dr.” Stearns. In 1751, Benjamin Franklin recognized the need for a home herbal, and reprinted Thomas Short’s Medicina Britannica: or A Treatise on such physical Plants as are generally to be found in the fields or gardens in Great Britain: containing a particular account of Their nature, virtues, and uses. The Franklin reprint of the third edition was With a preface by Mr. John Bartram . . . and his notes . . . Showing the places where many of the described plants are to be found in these parts of America, Their differences in name, appearance and virtues, from those of the same kind in Europe; and an appendix, containing a description of a number of plants peculiar to America, Their uses, virtues, &c. The second title of this work is Descriptions, virtues, and uses of sundry plants of these Northern parts of America, and particularly of the Newly discovered Indian cure for the venereal disease.68 In the Appendix, there are sections on the gathering, drying, and preserving of plants, and on the preparation and use of domestic remedies. Bartram’s Appendix includes descriptions and uses of spikenard, wild sarsaparilla, fleabane, lizard tail or water dragon, horsebalm or stoneroot, bloodroot or puccoon, bellwort, tinkerweed or feverwort, stargrass or colic root, dogbane or Indian hemp, great blue lobelia, speedwell, and the Eupatoriums, Joe Pye weed and boneset.69 Bartram’s Indian cure for “the venereal disease” was Lobelia siphilitica or the great blue lobelia. It has been stated that this plant was the secret remedy of the American Indians, the secret having been purchased from them by Sir William Johnson (1715–1774), the British soldier and American pioneer who was appointed superintendent of the Six Nations. Both Kalm and Colden probably learned of lobelia as an “antisyphilitic” from Bartram.70

In Boston, in 1750, William Douglass (1691–1752)71 was the leading physician, and the only physician who had received the M.D. degree, having studied in Edinburgh, Paris, and Leyden. A Scotsman, he came to Boston around 1718 and, according to Viets, began his study of botany in Europe. Douglass wrote, “In the country near Boston, I have collected and described about eleven hundred indigenous species of plants, perhaps a few of them might be casually imported from Europe.”72 Douglass also stated that witchcraft referred to the study of poisons and qualities of herbs; thus, herb women were witches!73

But what of Douglass’s use of botanical drugs? Did he use American indigenous plants as did his correspondent Cadwallader Colden (1688–1776)? Another Scotsman with an Edinburgh M.D., Colden lived in New York state, corresponded with Linnaeus, John Bartram, Alexander Garden, Peter Collinson, and Jan Frederick Gronovius. Like Douglass, Colden collected plants around his home in Orange County, New York, but unlike Douglass he published his botanical works in the Acts of the Royal Academy of Uppsala (1749, 1751) wherein he described over three hundred American plants. Colden also wrote on medical botany, advocating poke as a cure for cancer; he also reported “on the virtues of the great water dock,” and on the antisyphilitic properties of the great blue lobelia. Was it from Colden that Douglass learned of Alexander Garden’s use in Charleston of the Indian pink, pinkroot, or warm grass as an anthelminthic, a remedy learned from the Cherokee Indians? Did he read “An Epistle to Dr. Mead concerning the Seneca Rattle-snake root,” by John Tennent, his Virginia counterpart, in the Edinburgh Medical Essays and Observations!74

Perhaps Douglass gleaned some of his information from William Salmon’s Pharmacopoeia or New London Dispensatory (1678)75 (we know that the Mathers owned this volume) or from the Edinburgh Dispensatory (published originally in London with other editions, 1699, 1722, 1735, 1744, 1756, 1774, 1788, 1792, 1803, 1817; by 1805, five reprints had appeared in America).76 Although we do not know of Douglass’s botanical remedies, we do know about his dispensing of such drugs. He wrote to Colden, in 1722, “We abound with Practitioners, though no other graduates than myself, we have fourteen Apothecary Shops in Boston, all our Practitioners dispense their own Medicines.”77

After the Revolutionary war, one of the needs of the new nation was to derive the greatest possible benefit from the natural resources of the country. Johann Schoepf, a German soldier in the English service and a physician-botanist, stayed in the United States to study its indigenous materia medica.78 He traveled through the country for more than a year and published, in 1787, Materia Medica Americana Potissimum Regni Vegetabilis. Schoepf’s work is based largely on the observations of the excellent American botanist G. H. E. Muhlenberg and the work of Bartram, John Clayton, Colden, Kalm, Catesby, and others. Schoepf wrote to Muhlenberg, “My lists (describing about 400 North American plants) make it certain that North America owns a rich indigenous materia medica in her plants and can find all she needs, apart from a few East Indian spices and plants, on her own soil.... I almost flatter myself in writing this little book to have rendered sufficient services to America to be pardoned for my assistance in combatting her.”79

The first medical school in the North American colonies was founded in Philadelphia, in 1765, only a short time before the outbreak of the Revolution. Dr. John Morgan, Professor of Medicine, also taught materia medica and botany. The botany was taken over in 1768 by Dr. Adam Kuhn, who had studied under Linnaeus.80 Apparently, he did not like botany and gave it up after one year, when he was replaced by Benjamin Smith Barton (1766–1815). Barton authored Collections for an Essay towards a Materia Medica (1798–1804), the first American materia medica, as a critique of the work of Schoepf. Barton also edited for the use of students and physicians in the University of Pennsylvania William Cullen’s Treatise of Materia Medica in 1812, adding notes on the uses of American plants. Medical botany was now becoming a part of American medical education.

At the Harvard Medical School, founded in 1782, Benjamin Waterhouse became the Professor of the Theory and Practice of Physic. Waterhouse dabbled in botany and wrote Heads of a Course of Lectures on Natural History (1810) and The Botanist81 (1811). He added absolutely nothing to medical botany; the use of botanical remedies that Waterhouse recommended to his students is revealed by his hortus siccus or herbarium, now at the Countway Library.82 Of the 220 specimens in this undated book, seventeen have medical annotations. A few examples will suffice:

1. Arum. The root is an excellent medicine but must be used when fresh.
2. Datura stramonium. The extract from this herb has proved to be the most successful remedy in spasmodic disorders. The subscriber having seen it cure the most obstinate hysterical complaints that were as violent as those of epilepsy. Dose from ½ grain to 3 grains observing accurately when the pupil of the eye dilates.
3. Phytolacca. Doctor Colden’s specific against cancer. The root may be given internally and has succeeded to use in gout and other obstinate disorders.
4. Blood root. The root of this plant is an excellent medicine that will be of great use in the practice. Given in the dose of 6 grains it acts as an emetic and if the quantities be lessened to the half part it is an excellent diaphoretic.

Benjamin Waterhouse was removed as Hersey Professor at Harvard in 1812, and Jacob Bigelow, m.d. (1787–1872), succeeded to the public lectures in botany in Boston. As a Harvard undergraduate, Bigelow had been introduced to anatomy through the lectures of Dr. John C. Warren and discovered that “a physician might be fluent and accomplished and serve his generation in other ways than as a mere vehicle of pills and plasters.” In 1809 he chose to go to the University of Pennsylvania to study with the famous doctors, Rush, Wistar, Physick, and Barton, who stimulated his interest in botany. Back in Boston in 1810, Bigelow made a collection of plants within a ten-mile radius of Boston that he described in his first book, Florula Bostoniensis (1814), described as “the first distinctive local flora published in America.” In 1815 he was appointed Lecturer in Materia Medica and Botany at Harvard.83

In 1817, 1818, and 1820, Bigelow’s three-volume classic appeared: American Medical Botany, Being a Collection of the Native Medicinal Plants, Concerning their Botanical History and Chemical Analysis, and Properties and Uses in Medicine, Diet, and the Arts, with Coloured Engravings. Bigelow incorporated the colonial botanical tradition; he quoted Gerard, Linnaeus, Schoepf, Thacher, Colden, Franklin, Kalm, Cutler, B. S. Barton, Josselyn, Muhlenberg, A. Wilson, John Lining, Garden, Macbride, Catesby, Tennent, Clayton, Hariot, Michaux, Pursh, Elliot, Withering, Fothergill, and Sir Hans Sloane. There is no dependence on European authority as Cutler was dependent on Withering. Here is the introduction of chemical concepts, with a definite tendency toward prescribing a specific remedy for a specific disease.

In 1820, Bigelow was chairman of a committee of five who edited the first United States Pharmacopoeia; Lyman Spalding, Eli Ives, Thomas T. Hewson, and Elisha DeButts were also on the committee. The Pharmacopoeia showed its debt to Dr. James Thacher’s The American New Dispensatory (1810) which was based on the 1808 Pharmacopoeia prepared by Drs. James Jackson and John Collins Warren, which in turn was based on the Edinburgh Dispensatory.

It had been exactly two centuries since the 1620 landing of the Mayflower, with the copy of Dodoens’s Herbal to serve as a botanical guide, to the 1820 publication of Bigelow’s final volume of American Medical Botany and the first United States Pharmacopoeia. In these two centuries, the use of the old Galenic botanical remedies was shaken but not gone; it was to recrudesce in the budding Thomsonian movement. Finally, medical botany had become the province of the rising medical practitioners.

Perhaps the most active ingredient in the colonial botanic remedies was revealed in Dr. Stafford’s letter to Winthrop in 1643: “A man is not to neglect that partie, to whom he hath once administered, but to visit him at least once a day, and to meddle with no more, than he can well attend. In so doing he shall discharge a good conscience before God & man.”84

Acknowledgements I would like to thank Barbara Hill, Monique Richardson, and Barbara Greehey of the Library of the Massachusetts College of Pharmacy for their gracious assistance in finding source materials; and Richard J. Wolfe of the Rare Books Department of the Francis A. Countway Library of Medicine. My wife, Laura, hauled books, checked references, typed copy and made it all a pleasant task. This article is dedicated to her.

* Speaker

1. David Hawke, The Colonial Experience (Indianapolis, 1966), 255.

2. Evarts B. Greene and Virginia D. Harrington, American Population before the Federal Census of 1790 (New York, 1932), 6.

3. John M. Murrin, “Review Essay,” History and Theory: Studies in the Philosophy of History, 11 (1972), 248.

4. Ibid., 256, fn. 63.

5. Ibid., 256.

6. Carl Bridenbaugh, Cities in the Wilderness: The First Century of Urban Life in America, 1625–1742 (New York, 1955), 6, 143, 303.

7. Carl Bridenbaugh, Cities in Revolt: Urban Life in America, 1743–1776, Oxford paperback ed. (New York, 1971), 5, 216.

8. James T. Adams, New England in the Republic, 1776–1850 (Boston, 1926), 54.

9. The articles on religion and the 1795 vote on the calling of another constitutional convention did not receive a two-thirds vote but were declared accepted nonetheless. See Allan Nevins, The American States during and after the Revolution, 1775–1789 (New York, 1924), 181. In the gubernatorial elections between 1780 and 1789 the voter turnout ranged between nine and thirty-two percent. See R. R. Palmer, The Age of the Democratic Revolution: A Political History of Europe and America, 1760–1800, 2 v. (Princeton, N.J., 1959), I, 227–228, fn. 19; and J. R. Pole, Political Representation in England and the Origins of the American Republic (New York, 1966), 542.

10. Delegates from coastal and island counties voted 102 to 19 in favor of the new Constitution, while those from inland counties voted 128 to 60 against. See Samuel Eliot Morison, The Maritime History of Massachusetts, Sentry ed. (Boston, 1961), 39–40.

11. Greene and Harrington, Population, 18; Bureau of the Census, Historical Statistics of the United States, Colonial Times to 1970, 2 vols. (Washington, 1975), i, 29.

1. John A. Schutz and Douglass Adair, eds., The Spur of Fame: Dialogues of John Adams and Benjamin Rush, 1805–1813 (San Marino, Calif., 1966), 44.

2. As their later writings clearly reveal, Shryock and Bell followed up many of their own suggestions. Between the two of them, however, more ideas were produced than they alone could tackle. Some of the topics identified by them as significant and worthy of in-depth investigation became scholarly monographs, such as John Duffy’s Epidemics in Colonial America (Baton Rouge, La., 1953) and John B. Blake’s Public Health in the Town of Boston, 1630–1822 (Cambridge, Mass., 1959).

3. Francisco Guerra, American Medical Bibliography, 1639–1783 (New York, 1962); Genevieve Miller, Bibliography of the History of Medicine of the United States and Canada, 1939–1960 (Baltimore, 1964).

1. John B. Blake, ed., Education in the History of Medicine (New York, 1968), 114, 121, For a 1904 rationale for medical history, see: Henry E. Sigerist, “Medical History in the United States: Past—Present—Future: A Valedictory Address,” Bulletin of the History of Medicine, 22 (1948), 47–64. Although a 1956 symposium was charged to explore whether medical history can “illuminate current problems and issues in medicine,” its published proceedings show that it did not do so: lago Goldston, ed., On the Utility of Medical History (New York, 1957). In 1969 Genevieve Miller reported on reasons for the disappearance of medical history from medical school curricula in: Bulletin of the History of Medicine, 43 (1969), 259, 344, 444, 553. Participants in an unpublished symposium on “The Implications of Current Trends in Medical Education for the Teaching of Medical History” at the American Association for the History of Medicine annual meeting in Montreal, Canada, 3–5 May 1972, blamed the chasm between historians and practitioners (including students) of medicine at least partly on an unwillingness among scholars without M.D. degrees to adapt their scholarship to the emotional, cognitive, attitudinal, and intellectual needs of medical students, and on the rapid compression of medical curricula. Newly evolving approaches to the overall problem were only lightly sketched by Stanley Joel Reiser in “The History of Medicine Program at Harvard,” Bulletin of the History of Medicine, 46 (1972), 190–191.

2. Lester S. King, “Why Celebrate?” Journal of the American Medical Association, 236 (1976), 40.

3. Thomas S. Kuhn, The Structure of Scientific Revolutions, 2nd ed. (Chicago, 1970), 1.

4. Jonathan Swift, Gulliver’s Travels. See Gulliver’s visit to the Academy of Lagado on his voyage to Balnibarbi, in any standard edition. Gulliver’s medical training was among the best obtainable in the late seventeenth century. After a four-year apprenticeship to a London surgeon, Mr. James Bates, he studied physic for another two and a half years at Leyden, but before Boerhaave was appointed professor there in 1701. Electing a career as a ship’s surgeon, Gulliver had already spent over ten years at sea before he landed on Lilliput in 1699.

* After taking his A.B. in History at Oberlin College, Dr. Brown earned his A.M. and Ph.D., also in History, at Harvard. He is now Professor and Chairman of the History Department at the University of Connecticut at Storrs. His recent books that complement this paper include: Revolutionary Politics in Massachusetts: The Boston Committee of Correspondence and the Town (1970); Modernization: The Transformation of American Life, 1600–1865 (1976); and Massachusetts: A Bicentennial History (1978).

1. The population figure of 300,000 is an estimate of the combined populations of Massachusetts and Maine. According to Historical Statistics of the United States, Colonial Times to 1970, part 2 (Washington, D.C., 1975), 1168, the population was 267,000 in 1770. Assuming a growth rate of 2.5 percent per annum the population would have exceeded 300,000 by 1775. Robert V. Wells, author of The Population of the British Colonies in America before 1776 (Princeton, N.J., 1975), estimates the population at between 310,000 and 320,000 in 1775 (personal letter, 9 March 1979). James Potter, in “Growth of Population in America, 1700–1870,” in D. V. Glass and D. E. C. Eversley, eds., Population in History (Chicago, 1965), 638, puts the population at 339,000 in 1775, but his estimate projects an annual growth of over three percent. Comparison of birthrates and longevity is with English and European populations, although it is generally believed that natural increase was greater in New England than elsewhere in Anglo-America in the seventeenth century and that life expectancy was greater in the eighteenth century as well. See: Daniel Scott Smith, “The Demographic History of Colonial New England,” Journal of Economic History, 32 (1972), 165–183, esp. 165–170; Maris A. Vinovskis, “Mortality Rates and Trends in Massachusetts before 1860,” Journal of Economic History, 32 (1972), 184–213, esp. 195–202.

2. Kenneth A. Lockridge, Literacy in Colonial New England (New York, 1974), 98–99.

3. The rising popularity of almanacs during the course of the eighteenth century was partly based on their agricultural utility. Surviving almanac-diaries commonly include information on planting and harvest dates and yields. Almanacs also facilitated “moon farming,” a system of agricultural practices calculated according to the phases of the moon. See also: Robert A. Gross, “The Problem of Agricultural Crisis in Eighteenth-Century New England: Concord, Massachusetts, as a Test Case,” paper presented at American Historical Association Meeting, Atlanta, Ga., 29 Dec. 1975; Gross, “Minutemen in a New Nation: Concord, Massachusetts, in the 1790’s,” revised manuscript of a paper presented at the Historical Deerfield Conference on New England Towns in the Early National Period, 8 Dec. 1973.

4. John Clive and Bernard Bailyn, “England’s Cultural Provinces: Scotland and America,” William and Mary Quarterly, 3rd ser., 11 (1954), 200–213.

5. Keith Thomas, Religion and the Decline of Magic (New York, 1971).

6. David E. Stannard, The Puritan Way of Death (New York, 1977), ch. 4, “Death and Dying.”

7. From stone of Seth Sumner, Milton, Mass., 11 Nov. 1771. Quoted in Dickran and Ann Tashjian, Memorials for Children of Change: The Art of Early New England Stonecarving (Middletown, Ct., 1974), 245.

8. 29 Feb. 1730, Barnstable, Mass. Recorded by author.

9. Although there was conflict between some aspects of science and Protestant belief in the eighteenth century, medicine and theology were compatible; indeed Cotton Mather, a leading divine, was an advanced medical thinker (Perry Miller, New England Mind: From Colony to Province [Boston, 1961], 443). A few physicians were privately skeptics in religion, but medicine itself was a Christian profession. See: Whitfield J. Bell, Jr., The Colonial Physician and Other Essays (New York, 1975), 20–21. The existence of God was said to be demonstrated by scientific knowledge.

10. Christianson has found evidence of 149 practitioners in the colony before 1700, and one-half of them continued their activities after that date. He dates the substantial increase in the medical corps from the mid-eighteenth century (see Eric H. Christianson, “The Medical Practitioners of Massachusetts, 1630–1800,” below, 49–67).

11. Virgil J. Vogel, “American Indian Influence on the Pharmacopeia,” American Indian Culture and Research Journal, 2 (1977), 3–7; and Vogel, American Indian Medicine (Norman, Okla., 1970), 41–45. J. Worth Estes notes the use of Indian therapies and native American plants in “Honest Dr. Thornton: The Path to Rebellion,” in George E. Gifford, Jr., ed., Physician Signers of the Declaration of Independence (New York, 1976), 73–74.

12. William G. Rothstein, American Physicians in the Nineteenth Century: From Sects to Science (Baltimore, 1972), 36–37.

13. Christianson, “The Medical Practitioners of Massachusetts, 1630–1800.” J. Worth Estes notes that the medical experience of a Leicester, Massachusetts, cleric was by no means unusual since it was commonly expected that a minister would “fill both the medical and religious needs of his parish” (“Honest Dr. Thornton,” p. 71, see n. 11).

14. Whitfield J. Bell, Jr., considers the Boston-Philadelphia comparison below. See his “Medicine in Boston and Philadelphia: Comparisons and Contrasts, 1750–1820,” 159–184.

15. The American Antiquarian Society’s copy of William Buchan, Domestic Medicine: or, a Treatise on the Prevention and Cure of Diseases by Regimen and Simple Medicines, 14th ed. (Boston, 1793), contains a pasted-in newspaper remedy. Buchan’s Domestic Medicine was first published at London in 1769.

16. Eric H. Christianson, “The Medical Practitioners of Massachusetts, 1630–1800” (below, 49–67), has found that the self-taught “doctor” was most common. Douglas L. Jones, “Charity, Medical Charity, and Dependency in Eighteenth-Century Essex County, Massachusetts” (below, 199–213), demonstrates that people who became town charges often received treatment from the most learned physician in their locale.

17. According to the Oxford English Dictionary (Oxford, 1933; reprinted 1961), VIII, 929, the term “placebo” first appeared in a medical dictionary in 1811. Since dictionaries have typically lagged behind current usage, it would not be surprising if the term was in use among eighteenth-century medical practitioners; certainly the concept was known.

18. Joseph F. Kett, The Formation of the American Medical Profession: The Role of Institutions, 1780–1860 (New Haven, 1968), 5.

19. John M. Murrin, “The Myths of Colonial Democracy and Royal Decline in Eighteenth-Century America: A Review Essay,” Cithera, 5 (1965), 53–69.

20. Quoted in James H. Stark, The Loyalists of Massachusetts and the Other Side of the American Revolution (Boston, 1910), 386.

21. Biographical sketches in E. Alfred Jones, The Loyalists of Massachusetts: Their Memorials, Petitions and Claims (London, 1930), 140–142, 179–181, 233. (See Philip Cash, “The Professionalization of Boston Medicine, 1760–1803,” below, 69–100.—eds.)

22. First series given in 1765 by William Perkins. Albert Matthews, “Notes on Dr. William Perkins (1737–1797),” PtMications of the Colonial Society of Massachusetts, 20 (1917–1919), 10–17.

23. Philip Cash, “The Professionalization of Boston Medicine, 1760–1803” (below, 69–100), notes that military service often provided supplementary medical training. Cash also describes the shift in political influence from Tory to Patriot physicians. In his Medical Men at the Siege of Boston (Philadelphia, 1973) Cash estimated that some 140 “doctors” served the revolutionaries at Boston. The social characteristics and medical training of most of these men (sixty-nine percent) are unknown. Among the forty-three whose careers could be discovered Cash found that they were mostly young men from Massachusetts (twenty-six years of age on average), and possessed of limited medical experience. Less than half had attended college. Presumably the ninety-seven others whose careers could not be traced were even less well educated.

24. Walter Muir Whitehill, “Early Learned Societies in Boston and Vicinity,” in The Pursuit of Knowledge in the Early American Republic: American Scientific and Learned Societies from Colonial Times to the Civil War, Alexandra Oleson and Sanborn C. Brown, eds. (Baltimore, 1976), 151–173.

25. Information on the early purposes and membership is drawn from Massachusetts Medical Society, Medical Papers Communicated to the Massachusetts Medical Society, To Which Are Subjoined Extracts from various Authors, containing some of the Improvements, which have lately been made in Physic and Surgery (Boston, 1790), Evans no. 22661; Kett, Formation of the American Medical Profession, 15.

26. Massachusetts Medical Society, Medical Papers (see n. 25).

27. Ibid., iii–iv.

28. Ibid., vii.

29. Ibid., vii.

30. On the continuing vitality of popular medicine see: Guenter B. Risse, Ronald L. Numbers, and Judith Walzer Leavitt, eds., Medicine without Doctors: Home Health Care in American History (New York, 1977).

* Dr. Christianson, who is currently Assistant Professor of History at the University of Kentucky, Lexington, received his A.B., A.M., and Ph.D. degrees in History from the University of Southern California. His research and teaching encompass the history of science, medicine, and several of their branches. He is now working on a study of the Medical Department of Transylvania University at Lexington.

1. Medical Essays (Boston, 1911), 312, 352–353.

2. The Early History of the Medical Profession in Norfolk County, Massachusetts: An Address before the Norfolk District Medical Society, May 10, 1853 (Boston, 1853), 6.

3. Whitfield J. Bell, Jr., “A Portrait of the Colonial Physician,” Bulletin of the History of Medicine, 44 (1970), 497–517.

4. Certainly one of the first to recommend this approach is Bell, “Suggestions for Research in the Local History of Medicine in the United States,” Bulletin of the History of Medicine, 17 (1945), 460–476.

5. An excellent discussion of this technique is Lawrence Stone, “Prosopography,” Daedalus, 100 (1971), 46–79. Though not a computerized study, Steven Shapin and Arnold Thackray, “Prosopography as a Research Tool in the History of Science: The British Scientific Community, 1700–1800,” History of Science, 12 (1974), 1–28, demonstrate persuasively the analytical potential of collective biography. The pioneer effort to employ computer analysis of collective biography in American medical history is Barnes Riznik, “The Professional Lives of Early Nineteenth Century New England Doctors,” Journal of the History of Medicine and Allied Sciences, 19 (1964), 1–16. One exceptionally solid project examining demographic aspects of an occupational group is Harry S. Stout, “University Men in New England, 1620–1660: A Demographic Analysis,” Journal of Interdisciplinary History, 4 (1974), 375–400.

6. Two fine works in this area are Peter Laslett, The World We Have Lost (London, 1965), and Robert A. Gross, The Minutemen and Their World (New York, 1976). Unless otherwise noted, the charts and other statistical material in this paper are taken from my doctoral dissertation, “Individuals in the Healing Arts and the Emergence of a Medical Community in Massachusetts, 1700–1792: A Collective Biography” (University of Southern California, 1976).

7. Among others, the Reverend Dr. Cotton Mather discussed the importance of the rninister-doctor especially in the absence of trained individuals in developing regions. Robert Heller argues that the problems of health care in rural areas during the eighteenth century are a “mirror image of the situation in the developing countries” of the Third World (“ ‘Priest-doctors’ as a Rural Health Service in the Age of Enlightenment,” Medical History, 20 [1976], 361–383). (See Richard D. Brown, “The Healing Arts in Colonial and Revolutionary Massachusetts,” above, 35–47.—eds.)

8. In my attempt to reconstruct the composition of the first Boston Medical Society (1735– c. 1741), I discovered that Ezekiel Hersey, a pupil of Dr. Hugh Kennedy of Scotland, was inoculated for smallpox. Kennedy had to visit a patient out of town, so a nurse was summoned to care for Hersey. Because he was only a pupil, not an apprentice, Hersey was sued by his mentor for the nurse’s fees. The nurse, Sarah Melendy, gave her deposition and it can be profitably perused in the Court Files of the Superior Court of Suffolk County, Mass., February 1736/7, ccxc, 92–97.

9. For developments in England during a later period, see Joseph F. Kett, “Provincial Medical Practice in England, 1730–1815,” Journal of the History of Medicine and Allied Sciences, 19 (1964), 17–30.

10. History of Medicine in Massachusetts (Boston, 1881), 15.

11. Henry R. Viets, A Brief History of Medicine in Massachusetts (Boston, 1930), 11–12.

12. The Americans: The Colonial Experience (New York, 1958), 229.

13. A Directory of English Country Physicians, 1603–1643 (London, 1962), 12–14.

14. Gloria L. Main, “Inequality in Early America: The Evidence from Probate Records of Massachusetts and Maryland,” Journal of Interdisciplinary History, 7 (1977), 559–581.

15. Example-Title Styled at Death, abstracted from my dissertation (n. 6):

Title	N	% of total
Medical	861	62.8
Medical & other	13	.9
Esquire	20	1.5
Deacon	1	1
Other	42	3.1
Missing*	433	31.6
Totals	1370	100.0%

*Includes also those individuals for whom no title exists in the records.

16. Laslett, The World We Have Lost, 266.

17. I wish to thank Professor J. Worth Estes, m.d., of the Boston University School of Medicine, for this observation based on my original growth-rate figures.

18. While there are no comprehensive analyses for other areas with which to compare the results of the present study, two scholars have estimated that during the period 1607–1800 New Jersey had 300 medical inhabitants and Virginia 927 (David L. Cowen, Medicine and Health in New Jersey: A History [New Brunswick, 1964], 8; Wyndham B. Blanton, Medicine in Virginia in the Seventeenth Century [Richmond, 1930], 260–297, and Medicine in Virginia in the Eighteenth Century [Richmond, 1931], 313).

19. Contributions to the Annals of Medical Progress and Medical Education in the United States Before and During The War of Independence (Washington, D.C., 1874), 105–106.

20. Richard H. Shryock, Medicine and Society in America, 1660–1860 (Ithaca, 1962), 12.

21. Richard D. Brown, “The Emergence of Urban Society in Rural Massachusetts, 1760–1820,” Journal of American History, 61 (1974), 29–51.

22. Eric H. Christianson, “The Emergence of Medical Communities in Massachusetts, 1700–1794: The Demographic Factors,” unpublished paper read at the 50th Annual Meeting of the American Association for the History of Medicine, 13 May 1977, Madison, Wisconsin. The selection of towns includes Attleborough, Becket, Billerica, Boston, Boxford, Bridgewater, Brookline, Charlton, Chilmark, Great Barrington, Medford, Newbury, Northampton, Pittsfield, Plymouth, Rehoboth, Salem, Taunton, Tyringham, and Worcester.

23. Also see J. Worth Estes, “Therapeutic Practice in Colonial New England,” below, 289–383; and the Appendix to C. Helen Brock, “The Influence of Europe on Colonial Massachusetts Medicine,” below, 101–143.—eds.

24. Helpful observations on mobility during the eighteenth century in several locations are found in Gross, 90–91 (fn. 6), and Philip J. Greven, Jr., Four Generations: Population, Land, and Family in Colonial Andover, Massachusetts (Ithaca, 1970), 156–157, 162–163, 254–256.

25. T. H. Breen and Stephen Foster, “The Way to the New World: The Character of Early Massachusetts Immigration,” William and Mary Quarterly, 30 (1973), 189–222.

26. Christianson, “The Emergence of Medical Communities in Massachusetts, 1700–1794” (see n. 11).

27. Similar figures for the antebellum period are presented in Riznik (n. 5), 1–13, and in Charles McIntyre, “The Percentage of College-Bred Men in the Medical Profession,” Medical Record, 22 (1882), 681–684.

28. Christianson (n. 22).

29. Richard D. Brown, Modernization: The Transformation of American Life, 16001865 (New York, 1976), 74–121.

30. The quote is from James A. Henretta, The Evolution of American Society, 1700–1815 (Lexington, Mass., 1973), 209. The problem of how difficult it is to determine the efficacy of learned and home remedies is discussed in my article “The Description and Treatment of the Fly-Blown Ear: An Aspect of Science and Medicine in Colonial America,” The Melsheimer Entomological Series, 26 (1979), 1–12.

31. Nathaniel Ames, Jr., “An Elegy On the Death of the Late Dr. Ames,” in An Astronomical Diary, or Almanack, for . . . 1765 (Boston, 1764), n.p.

32. Education in the Forming of American Society: Needs and Opportunities for Study (Chapel Hill, N.C., 1960), 30–31.

33. Rhoda Truax, The Doctors Warren of Boston, First Family of Surgery (Boston, 1968), 85.

34. Viets (n. 11), 94–95, observes that in Boston the loyalist physicians did not fare well, but away from the hub of activity the loyalist might be watched carefully but tolerated.

35. In 1738, after ten years without a resident doctor, Northampton, along with four other neighboring towns, jointly extended an offer of £200 to Hezekiah Porter of Farmington, Connecticut, provided that he “lived among us Some years” (Northampton Town Records quoted in James Russell Trumbull, History of Northampton, Massachusetts [Northampton, 1902], II, 85–86).

36. Christianson (n. 6), 161–163, 168–171.

37. Riznik (n. 5), 3–6; William Barlow and David O. Powell, “To Find a Stand: New England Physicians on the Western Frontier, 1790–1840,” unpublished paper delivered at the 50th Annual Meeting of the American Association for the History of Medicine, 13 May 1977, Madison, Wisconsin.

38. Professional Lives in America: Structure and Aspirations, 1750–1850 (Cambridge, Mass., 1965), 55. Professor Estes demonstrates elsewhere in this volume that in New England doctors in large communities recorded a higher patient load than did their country counterparts and made more money, and that their therapies differed to some extent. Also, in another article (“ ‘As Healthy a Place as Any in America’: Revolutionary Portsmouth, N.H.,” Bulletin of the History of Medicine, 50 [1976], 536–552) he describes the greater longevity among residents of smaller towns than among their city counterparts. Few practitioners in either situation became wealthy from their patients’ fees, but it may be that inhabitants of larger towns, where mortality rates were higher, might have required greater medical attention and yielded more professional income. The city doctor, in effect, might not have to wait as long to collect fees from his deceased patients’ estates. On the other hand, it is possible that rural doctors received over a longer period of time a constant but modest income from their patients. A “surplus” of doctors in the countryside might then be heightened by their patients’ greater longevity.

39. The Doctor Shortage: An Economic Diagnosis (Washington, D.C., 1967), 5–8.

40. An excellent anthology covering the vitality of the self-help tradition in American history is Guenther B. Risse, Ronald L. Numbers, and Judith Walzer Leavitt, eds., Medicine without Doctors: Home Health Care in American History (New York, 1977). Henretta (n. 30), 111, stated that a deferential society persisted in New England and that the masses deferred to the leading families. Such customs might also explain the apparent success of medical family members in driving out the mobile interloper. “It could be said that the advent of universal literacy [in post-1760 New England] would have increased both the unity of men and their contentiousness, in a paradox typical of the modernization of attitudes” (Kenneth A. Lockridge, Literacy in Colonial New England: An Inquiry into the Social Context of Literacy in the Early Modern West [New York, 1974], 29).

41. Ames, “An Elegy . . .” (n. 31).

42. This quote is from the famous “Graph Iatroon” letter announcing in March 1765 the formation, without realization, of a medical society composed of doctors living around, but not in, Boston (Walter L. Burrage, A History of the Massachusetts Medical Society with Brief Biographies of the Founders and Chief Officers, 1781–1922 [1923], 3–4).

43. “Medicine and Learned Societies in the United States, 1660–1865,” in Alexandra Oleson and Sanborn C. Brown, eds., The Pursuit of Knowledge in the Early American Republic: American Scientific and Learned Societies from Colonial Times to the Civil War (Baltimore and London, 1976), 261–278.

44. Richard D. Brown, “The Emergence of Voluntary Associations in Massachusetts, 1760–1830,” Journal of the Volunteer Active Reserves, 2 (1973), 64–73.

45. One need only peruse chapters II, III, and X in Burrage (n. 42), to capture the flavor of ambivalence.

46. The manuscript collection pertaining to the early history of the state society contains dozens of letters written by members from all over the state making suggestions about educational qualifications for competent practice (b.ms.b.75.1, Boston Medical Library, Francis A. Countway Library of Medicine).

47. In 1755, young Bostonian William Jepson, a former pupil of Dr. Silvester Gardiner, enumerated the “many disadvantages attending a seperate [sic] way of study” in the bylaws of a group composed of recent apprenticeship graduates for the purpose of continuing their training throughout their careers (uncatalogued Silvester Gardiner Papers, Francis A. Countway Library of Medicine).

48. One of the rules governing the Berkshire Medical Association, which was located in Stockbridge, indicates the willingness of some regularly trained men to join forces with the opposition: “Any person residing within the limits of this county, and pretending to practice physic and shall refuse ... to become a member ... he shall be treated with entire neglect” (manuscript records of the Berkshire District Medical Society, 1785–1864, Berkshire Medical Institution, Pittsfield, 3–27).

49. For a detailed discussion of that ill-fated group, see Christianson (n. 6), 155–161.

50. The Rise, Progress, and Present State of Medicine, Delivered at Concord July 6, 1791, before the Middlesex Medical Association (Boston, 1792), 28. Such discord was “highly detrimental to the Profession” and provided the “chief Root from whence these very Empiricks spring” (Burrage [n. 42], 3–4).

51. Israel Atherton to M.M.S., Lancaster, 20 October 1789 (b.ms.b.75.1 f72, Boston Medical Library, Francis A. Countway Library of Medicine).

52. Calhoun (n. 38), 55.

53. Berkshire District Medical Society Records (n. 48), 5, 10.

54. Michael Zuckerman, “The Fabrication of Identity in Early America,” William and Mary Quarterly, 34 (1977), 183–214.

55. The motto coined by Theodore Parker in 1848 and quoted in Michael Kammen, People of Paradox: An Inquiry Concerning the Origins of American Civilization (New York, 1973), 57.

56. Two works detailing these developments are Joseph F. Kett, The Formation of the American Medical Profession: The Role of Institutions, 1780–1860 (New Haven, 1968), and William G. Rothstein, American Physicians in the Nineteenth Century: From Sects to Science (Baltimore and London, 1972).

* After obtaining his B.S.Ed, at Gorham State Teachers College in Maine, Dr. Cash completed his studies in History at Boston College, where he earned his M.A. and Ph.D. degrees. He is now Professor of History at Emmanuel College in Boston, where he was Chairman of the Department for nine years. His other contributions to colonial medical studies include a chapter on Dr. Oliver Wolcott of Litchfield, Connecticut, in Physician Signers of the Declaration of Independence (1976), and a book on Medical Men at the Siege of Boston, April, 1775–April, 1776: Problems of the Massachusetts and Continental Armies (1973).

1. The use of the term “professionalization” in this paper may not conform to some contemporary sociological models. It is used as a term of practicality or convenience. By it I mean an increased sense of awareness of common goals and common aspirations on the part of Boston’s trained medical practitioners (physicians) of this era. This was demonstrated primarily in increased cooperation, attempts to improve medical training, and in attempts to gain greater control over the dispensing of medical services. It also involved the founding of two medical societies and a medical school. I recognize that there was a medical profession in Boston before 1760 and that the process of professionalization continued after 1803.

2. For developments in Philadelphia at this time see Whitfield J. Bell, Jr., “Medicine in Boston and Philadelphia: Comparisons and Contrasts,” below, 159–184.—eds.

3. In analyzing the professionalization of Boston medicine between 1760 and 1803 I have considered as “physicians” only those practitioners of medicine who had undergone at least a medical pupilage or apprenticeship and who were engaged in medical practice for at least five years, including any military medical service. Admittedly, this definition is somewhat arbitrary and not wholly in keeping with contemporary usage. However, these limitations are more than offset by the fact that it provides for far greater clarity and precision of usage and allows for a systematic analysis of that element among the variegated purveyors of medical service in eighteenth-century America who would evolve into the modern doctor. So far I have been able to identify and confirm forty-seven men who meet these criteria and who were members of the Boston medical community between 1760 and 1798, although in several instances the fact of their pupilage or apprenticeship must be inferred from substantial but indirect evidence. Undoubtedly there were others who practiced in Boston during this time and who meet the above criteria, but whom I have not been able to identify or confirm. However, it is unlikely that they would seriously alter the professional profile that I have drawn. I have listed these men in Appendix I together with pertinent data as to their college education, medical training above the apprenticeship-pupilage level, military medical experience, and religious and political affiliations. In identifying and listing these men I have used 1798 rather than 1803 as the cutoff date in order to avoid including such people as James Jackson and John Collins Warren who really belong to the next generation and next era of Boston medicine. The fourteen physicians who were practicing in Boston in 1760 were: Thomas Bulfinch, Jr.; Benjamin Church, Jr.; John Clark rv; Nyott Doubt; Silvester Gardiner; Joseph Gardner; James Lloyd; Thomas Mather; James Pecker; John Perkins; Nathaniel Perkins; William Lee Perkins; John Sprague; and Miles Whitworth, Sr. The twenty-one who were active at the opening of 1775 were: Samuel Adams, Jr.; Thomas Bulfinch, Jr.; Benjamin Church, jr.; Samuel Danforth; Silvester Gardiner; Joseph Gardner; Ebenezer Hunt; Charles Jarvis; John Jeffries; Thomas Kast; James Lloyd; James Pecker; John Perkins; Nathaniel Perkins; William Lee Perkins; Isaac Rand, Jr.; John Sprague; Joseph Warren; Miles Whitworth, Sr.; Amos Windship; and Thomas Young.

4. By 1760 Boston was a city in deep economic, social, and political trouble because of the residue of bitterness left over from the monetary struggles of the 1740’s and early ‘50’s, the serious economic and human losses sustained in the last two colonial wars, and the growing competition for markets offered by commercial rivals both large and small and near and far. Between 1760 and 1764 the city was ravaged by the greatest of many fires during the colonial era and then further disrupted by a major smallpox epidemic. Over the next decade a generally depressed economy and bitter political struggle punctuated by military occupation beset the city until the news of Lexington and Concord must have come as psychic relief. See James T. Adams, Revolutionary New England, 1691–1776 (Boston, 1923), 138–416; Carl Bridenbaugh, Cities in Revolt: Urban Life in America, 1743–1776 (1955; rpt. ed., New York, 1971); Samuel G. Drake, The History and Antiquities of Boston, the Capital of Massachusetts and Metropolis of New England, from its Settlement in 1630 to the Year 1770 (Boston, 1856), 637–784; Albert B. Hart, ed., Commonwealth History of Massachusetts, 5 v. (New York, 1927–1930), II and III; James A. Henretta, “Economic Development and Social Structure in Colonial Boston,” William and Mary Quarterly, 22 (1965), 75–92; Gerald B. Warden, “The Distribution of Property in Boston, 1692–1775,” Perspectives in American History, 10 (1976), 81–130; Gerald B. Warden, Boston, 1689–1776 (Boston, 1970), 127–143; William B. Weeden, Economic and Social History of New England, 1620–1789, 2 v. (Boston, 1890), II, 637–767; Justin Winsor, ed., Memorial History of Boston, Including Suffolk County, 1630–1880, 4 v. (Boston, 1880–1881), III, 1–67, 119–175. For the permanent population of Boston during this period see Lemuel Shattuck, Report to the Committee of the City Council Appointed to Obtain the Census for Boston for the Year 1845 (Boston, 1846), 3–5, 54; Bridenbaugh, Revolt, 5, 216, 497, fn. 328:1.

5. For doctors in the colony as a whole see Eric H. Christianson, “The Medical Practitioners of Massachusetts, 1630–1800: Patterns of Change and Continuity,” above, 49–67.—eds.

6. John Langdon Sibley and Clifford K. Shipton, Sibley’s Harvard Graduates, 17 v. so far (Cambridge, Mass., 1873–), viii, 90–92.

7. The thirteen who had studied in Europe were: Thomas Bulflnch, Jr.; Benjamin Church, Jr.; Samuel Danforth; Nyott Doubt; Silvester Gardiner; Charles Jarvis; John Jeffries; Thomas Kast; James Lloyd; Samuel Marshall; John Perkins; William Lee Perkins; and Williams Smibert. Of these, only Smibert (Edinburgh m.d., 1762) had not studied in London.

8. They were Thomas Bulfinch, Jr., and Williams Smibert (Edinburgh), and John Jeffries (Aberdeen). William Lee Perkins may have earned a medical degree but where or when is uncertain, and it is quite possible that he received it after leaving Boston in 1776.

9. See C. Helen Brock, “The Influence of Europe on Colonial Massachusetts Medicine,” below, 101–116, and its Appendix, 117–143.—eds.

10. See Brooke Hindle, The Pursuit of Science in Revolutionary America, 1735–1789 (Chapel Hill, N.C., 1956).

11. The exceptions were Thomas Kast, who was born in Boston but whose father had emigrated from Germany; John Linn, an incorporator of the Massachusetts Medical Society, who came from Pennsylvania and soon returned there; Williams Smibert, who very likely was the son of the Edinburgh-born painter John Smibert, who had emigrated to Rhode Island with Bishop Berkeley’s party in 1728; and Thomas Young, whose father had emigrated from Ireland to Ulster County, New York, where Young was born and raised.

12. Josiah Bartlett, “An Historical Sketch of the Progress of Medical Science in the Commonwealth of Massachusetts, being the Substance of A Discourse Read at the Annual Meeting of the Medical Society, June 6, 1810, with Alterations and Additions to January 1, 1813,” Massachusetts Historical Society Collections, 2nd ser., 1 (1814), 106–109; John B. Blake, “The Medical Profession and Public Health in Colonial Boston,” Bulletin of the History of Medicine, 26 (1952), 218–230; John B. Blake, “The Inoculation Controversy in Boston, 1721–1722,” The New England Quarterly, 25 (1952), 489–506; John B. Blake, “Smallpox Inoculation in Colonial Boston,” Journal of the History of Medicine and Allied Sciences, 8 (1953), 284–300; John B. Blake, Public Health in the Town of Boston, 1630–1822 (Cambridge, Mass., 1959), 52–88; Bridenbaugh, Revolt, 328–329; John Duffy, Epidemics in Colonial America (Baton Rouge, La., 1953). 103; Frederick G. Kilgour, “The Rise of Scientific Activity in Colonial New England,” Yale Journal of Biology and Medicine, 22 (1949–1950), 122–138; Joseph M. Toner, “History of Inoculation in Massachusetts,” Massachusetts Medical Society Publications, 2 (1867), 153–190; Ola E. Winslow, A Destroying Angel: The Conquest of Smallpox in Colonial Boston (Boston, 1974).

13. In March 1761, Silvester Gardiner, then the most distinguished physician in Boston, offered to construct a private inoculation hospital on a remote part of the Common near where he had earlier built a hospital for the British fleet in New England waters, but nothing came of it. In 1763, Thomas Bulfinch, Jr., Joseph Gardner, and Joseph Warren, who only recently had finished his training with James Lloyd, joined in an unsuccessful effort to secure permission to build a private inoculation hospital in or near Boston. See Boston Records Commissioners’ Reports, 16, 51–52; John Cary, Joseph Warren: Physician, Politician, Patriot (Urbana, Ill., 1961), 21; silvester Gardiner, “To the Freeholders and Other Inhabitants of the Town of Boston, in Town Meeting Assembled, March, 1761,” Massachusetts Historical Society Proceedings, ser. 1, 4 (1858–1860), 324–328; Maurice Bear Gordon, Aesculapius Comes to the Colonies: The Story of the Early Days of Medicine in the Thirteen Original Colonies (Ventnor, N.J., 1949), 89–90; Samuel Abbott Green, History of Medicine in Massachusetts: A Centennial Address Delivered Before the Massachusetts Medical Society At Cambridge, June 7, 1881 (Boston, 1881), 78; Henry R. Viets, A Brief History of Medicine in Massachusetts (Boston, 1930), 79.

14. Blake, “Inoculation,” 291; Boston Post-Boy and Advertiser, 26 March 1764; Boston Records Commissioners’ Reports, 16, 116–117; Cary, Joseph Warren, 22; Esther Forbes, Paul Revere and the World He Lived In (Boston, 1942), 75–76.

15. Bartlett, “Progress,” 108; Blake, “Inoculation,” 291–292; Boston Post-Boy and Advertiser, 27 February – 25 June 1764; Cary, Joseph Warren, 21–22; J. Worth Estes, Hall Jackson and the Purple Foxglove: Medical Practice and Research in Revolutionary America, 1760–1820 (Hanover, N.H., 1979), 16–21; Green, Massachusetts, 74–76; Massachusetts Gazette and Boston News-Letter, 8 March 1764; Toner, “Inoculation,” 180–184.

16. Blake, “Inoculation,” 291.

17. Blake, “Inoculation,” 292–295; Blake, Public Health, 92–96; Toner, “Inoculation,” 204, fn. 38.

18. Warren Papers, ii (1756–1799), Massachusetts Historical Society; Edward Warren, The Life of John Warren, M.D. (Boston, 1874), 21–22.

19. Certificate of Attendance by James Lloyd at two Courses on Midwifery by William Smellie, BMS Miscellany, Countway Library, Harvard Medical School; Edwin M. Jameson, “Eighteenth Century Obstetrics and Obstetricians in the United States,” Annals of Medical History, new ser., 10 (1938), 413–432; “Notice of the Late James Lloyd, m.d.,” New England Journal of Medicine and Surgery, and the Collateral Branches of Science, 2 (1813), 127–130; Shipton, Sibley’s, xii, 184–193; James Thacher, American Medical Biography, 2 v. in 1 (Boston, 1827), i, 359–376; Henry R. Viets, “James Lloyd,” DAB, xi, 332; Viets, Massachusetts, 72–74; Henry R. Viets, “The Medical Education of James Lloyd in Colonial America,” Yale Journal of Biology and Medicine, 31 (1958–1959), 1–14. See also a letter from Lloyd’s son, James, to James Thacher, dated 16 September 1829, inserted into a volume of Thacher’s American Medical Biography, inscribed to Dr. Edward Reynolds and now in the Countway Library, Harvard Medical School.

20. Ledger of James Lloyd, 1758–1778, Countway Library, Harvard Medical School. (See J. Worth Estes, “Therapeutic Practice in Colonial New England,” below, 289–383.—eds.)

21. Cary, Joseph Warren, 20; Shipton, Sibley’s, xii, 188–189; Thacher, Biography, I, 364; Viets, Massachusetts, 73–74, 86, 91–92. Ironically, by the late 1760’s Lloyd’s practice was so large that he could no longer be effective in carrying out his training reforms. See Shipton, Sibley’s, xviii, 188–190.

22. Albert Matthews, “Notes on Early Autopsies and Anatomical Lectures,” Colonial Society of Massachusetts Publications, 19 (1916–1917), 273–290; Frederick C. Waite, “The Development of Anatomical Laws in the States of New England,” New England Journal of Medicine, 233 (1945), 716–725.

23. Boston Gazette and Country Journal, 25 November 1765; Bridenbaugh, Revolt, 409; Cary, Joseph Warren, 33; E. Alfred Jones, The Loyalists of Massachusetts: Their Memorials, Petitions and Claims (London, 1930), 179–181, 233–234; Edward B. Krumbhaar, “Early History of Anatomy in the United States,” Annals of Medical History, 4 (1922), 282; Albert Matthews, “Notes on Dr. William Perkins (1737–1797),” Colonial Society of Massachusetts Publications, 20 (1917–1919), 10–17; Shipton, Sibley’s, xvii, 188–190. Jones mistakenly dates the Jeffries lectures as 1765, although he also credits the 1765 lectures to Perkins. See above.

24. Krumbhaar, “Anatomy,” 182.

25. Samuel F. Batchelder, Bits of Harvard History (Cambridge, Mass., 1924), 157–158; Bartlett, “Progress,” 105; Henry K. Beecher and Mark D. Altschule, Medicine at Harvard: The First Three Hundred Years (Hanover, N.H., 1977), 27; Cary, Joseph Warren, 31, 32, fn. 25; Matthews, “Autopsies,” 285–289; Thomas E. Moore, Jr., “The Early Years of the Harvard Medical School: Its Founding and Curriculum, 1782–1810,” honors thesis, Harvard University, 1952, 19–20; Francis R. Packard, History of Medicine in the United States, 2. v (New York, 1931; Hafner rpt., 1963), i, 430; Warren, John Warren, 23–26, 226–233.

26. Boston Post-Boy and Advertiser, 30 January 1764. Also see Green, Massachusetts, 76–77; Harvard Corporation Records, ii, 182, Harvard Archives, Pusey Library; Thomas F. Harrington, The Harvard Medical School: A History, Narrative, and Documentary, 1782–1905, 3 v., ed. James Mumford (New York, 1905), I, 32; Massachusetts Gazette and Boston News-Letter, 2 February 1764; Josiah Quincy, The History of Harvard University, 2 v. (Boston, 1860), ii, 480–482.

27. Quincy, Harvard, ii, 530–531.

28. Lawrence A. Cremin, American Education: The Colonial Experience, 1607–1783 (New York, 1970), 397; I. Bernard Cohen, Some Early Tools of American Science (Cambridge, Mass., 1950), 9–10.

29. Bartlett, “Progress,” 116; Boston News-Letter, 20 December 1770; Harrington, Harvard, i, 32–33; Harvard Corporation Records, ii, 350–351, 375–376, Harvard Archives, Pusey Library; Thomas E. Moore, Jr., “Early Years of the Harvard Medical School, 1782–1810,” Bulletin of the History of Medicine, 27 (1953), 530–531; Quincy, Harvard, ii, 212–213.

30. Harvard Corporation Records, ii, 378, Harvard Archives, Pusey Library. The “Reverend Dr. Erskine” continued to be a benefactor to Harvard until at least 1798. See Harvard Corporation Records, iii, 260, 307, 329–330, 396, 434, 438, 459, and iv, 535, Harvard Archives, Pusey Library.

31. Batchelder, Bits, 158; Francisco Guerra, American Medical Bibliography, 1639–1783 (New York, 1962), 533, 567, 647–651; Massachusetts Gazette and Boston Post-Boy and Advertiser, 14–28 November 1764; Massachusetts Gazette and Boston Weekly News-Letter, 12 January 1775.

32. They were John Clark vi, William Eustis, Martin Herrick, John Homans Samuel Tenney, Thomas Welsh, and Miles Whitworth, Jr. See Harvard University Quinquennial Catalogue of Officers and Graduates, 1636–1930 (Cambridge, Mass., 1930), 194–195; Viets, Massachusetts, 99.

33. The prime mover in the attempt to found a colonywide medical society in 1765 was Dr. Cotton Tufts of Weymouth, later a major force in the early years of the Massachusetts Medical Society. One of the physicians who gave him considerable support was a Joseph Gardner who Burrage says practiced in Milton and Dorchester. However, it seems likely that this was the Joseph Gardner who was a prominent physician in Boston at this time and who also was a leader in the early years of the Massachusetts Medical Society. No other Boston physician seems to have played a significant role. See Walter L. Burrage, A History of the Massachusetts Medical Society, with Brief Biographies of the Founders and Chief Officers, 1781–1922 (Norwood, Mass., 1923), 3, 62.

34. Boston Chronicle, 7 January 1768.

35. Burrage, Society, 21–22; Philip Cash, Medical Men at the Siege of Boston, April, 1775. April, 1776: Problems of the Massachusetts and Continental Armies (Philadelphia, 1973).

36. James T. Adams, New England in the Republic, 1776–1850 (Boston, 1926), 3–108; Forbes, Revere, 196–352; Allen French, The First Year of the American Revolution (New York, 1934); Hart, Commonwealth, iii, 1–354; M. A. DeWolfe Howe, Boston: The Place and the People (New York, 1903), 87–122; Allan Nevins, The American States during and after the Revolution, 1775–1789 (New York, 1924); Winsor, Boston, iii, 67–188.

37. The physicians known to have been practicing in Boston in 1776 include: Thomas Bulfinch, Jr.; William Clark; Samuel Danforth; Joseph Gardner; Ebenezer Hunt; Charles Jarvis; Thomas Kast; James Lloyd; James Pecker; John Perkins; Isaac Rand, Jr.; and John Sprague (part-time).

38. This included the thirteen members of the newly founded Boston Medical Society plus Thomas Bulfinch, Jr. See Burrage, Society, 19.

39. See William C. Wigglesworth, “Surgery in Massachusetts, 1620–1800,” below, 215–247.—eds.

40. Burrage, Society, 52–53, 55, 292; “Samuel Danforth,” Boston Medical and Surgical Journal, 1 (1828–1829), 17–21; Harvard Corporation Records, III, 148–149, 151, Harvard Archives, Pusey Library; Moore, “Years” (article), 537; Thacher, Biography, ii, 264–265; “Experiments on the Waters of Boston by Dr. Feron,” Warren Papers, ii (1780–1785), Massachusetts Historical Society; Warren, John Warren, 190–242, 418–420.

41. Bartlett, “Progress,” 111–112, 120–121; Beecher and Altschule, Harvard, 25; Burrage, Society, 13–15; Hindle, Pursuit, 263–268, 285–287, 290–292, 297–298, 357–358; Moore, “Years” (article), 534–535; Viets, Massachusetts, 104; Warren, John Warren, 233–237.

42. Beecher and Altschule, Harvard, 27; Boston Evening-Post and General Advertiser, 10 November 1781; Bulfinch to Boston Medical Society, 24 September 1780, Warren Papers, II (1780–1785), Massachusetts Historical Society; Burrage, Society, 19; Ephraim Eliot, “Dr. Ephraim Eliot’s Account of the Physicians of Boston,” Massachusetts Historical Society Proceedings, ser. 1, 7 (1863–1864), 181; Oscar and Mary Handlin, Commonwealth: A Study of the Role of Government in the American Economy: Massachusetts, 1744–1861, rev. ed. (Cambridge, Mass., 1969), 97; Harrington, Harvard, I, 77–79; Moore, “Years” (article), 533; Warren, John Warren, 222–225.

43. Boston Evening-Post and General Advertiser, 10 November 1781.

44. Beecher and Altschule, Harvard, 29; Eliot, “Account,” 181–182; Green, Massachusetts, 101–102; Harrington, Harvard, i, 77–79; Independent Chronicle and Universal Advertiser, 6–20 December 1781; James Jackson, A Eulogy on the Character of John Warren, M.D. (Boston, 1815), 14–15; Moore, “Years” (article), 534; Shipton, Sibley’s, xviii, 664; Thacher, Biography, ii, 258.

45. Beecher and Altschule, Harvard, 28; Burrage, Society, 16–19; Handlin, Commonwealth, 97; Joseph F. Kett, The Formation of the American Medical Profession: The Role of Institutions, 1780–1860 (New Haven, 1968), 14; Viets, Massachusetts, 103, 106.

46. For a list of the thirty-one incorporators, see Burrage, Society, 16.

47. Bartlett, “Progress,” 113–114; Beecher and Altschule, Harvard, 25, 28, 537, fn. 21; Burrage, Society, 1–75, 280–281, 301–313, 350–354, 388–400, 416–418; Joseph E. Garland, “Medical Journalism in New England, 1788–1924,” Boston Medical and Surgical Journal, 190 (1926), 865–879; Handlin, Commonwealth, 97, 208–209; Kett, Formation, 14–15, 24; Harold and James Kirker, Bulfinch’s Boston, 1787–1817 (New York, 1964), 224; Massachusetts Medical Society, Miscellany, i, Countway Library, Harvard Medical School; Warren, John Warren, 242.

48. By 1815 the library of the Massachusetts Medical Society contained about 4,000 volumes. See Kirker, Bulfinch’s, 224.

49. Burrage, Society, 463–467.

50. Burrage, Society, 44, 463–467.

51. Beecher and Altschule, Harvard, 27–28; Eliot, “Account,” 183–184; Lloyd to Massachusetts Medical Society, 5 November 1788, b.ms. c. 75.2, Countway Library, Harvard Medical School; Shipton, Sibley’s, xii 192–193; Viets, “Lloyd,” DAB, xi, 332.

52. Rhoda Truax, The Doctors Warren of Boston: First Family of Surgery (Boston, 1968), 88.

53. See Harvard Corporation Records, iii-v, passim, Harvard Archives, Pusey Library.

54. Beecher and Altschule, Harvard, 40–45; John B. Blake, Benjamin Waterhouse and the Introduction of Vaccination: A Reappraisal (Philadelphia, 1957); Cohen, Tools, 102–103; Jeanette E. Graustein, “Natural History at Harvard College, 1788–1842,” Cambridge Historical Society Publications, 38 (1959–1960), 73; William Coolidge Lane, “Dr. Benjamin Waterhouse and Harvard University,” Cambridge Historical Society Publications, 4 (1909), 5–22; Packard, Medicine, i, 433–445; William Roscoe Thayer, “Extracts from the Journal of Benjamin Waterhouse,” Cambridge Historical Society Publications, 4 (1909), 22–27; Josiah Charles Trent, “The London Years of Benjamin Waterhouse,” Journal of the History of Medicine and Allied Sciences, 1 (1946), 25–40; Josiah Charles Trent, “Benjamin Waterhouse (1754–1846),” Journal of the History of Medicine and Allied Sciences, 1 (1946), 357–364; Henry R. Viets, “Benjamin Waterhouse, m.d.” DAB, xix, 529–532; “Death of Benjamin Waterhouse, m.d.,” Boston Medical and Surgical Journal, 35 (1846–1847), 206.

55. See William Frederick Norwood, Medical Education in the United States before the Civil War (Philadelphia, 1944; Arno rpt., 1971).

56. Beecher and Altschule, Harvard, 31, 34; Burrage, Society, 19; Harrington, Harvard, i, 275; Moore, “Years” (article), 545–546; Packard, Medicine, i, 305–306; Barnes Riznik, Medicine in New England, 1790–1840: A Report Prepared by the Department of Research, Old Sturbridge Village (Sturbridge, Mass., 1963), 105–106; Warren, John Warren, 287–295.

57. Samuel Eliot Morison, Three Centuries of Harvard, 1636–1936 (Cambridge, Mass., 1936), 164–167, 174; Shipton, Sibley’s, xvi, 253–265. Willard was inducted into the Harvard presidency on 19 December 1781. See Harvard Corporation Records, iii, 134–136, Harvard Archives, Pusey Library.

58. Beecher and Altschule, Harvard, 29; Eliot, “Account,” 181–182; Green, Massachusetts, 101–102; Harrington, Harvard, i, 77–79; Independent Chronicle and Universal Advertiser, 6–20 December 1781; Jackson, Eulogy, 14–15; Kett, Profession, 72; Moore, “Years” (article), 534; Morison, Centuries, 168; Packard, Medicine, i, 430; Shipton, Sibley’s, viii, 664–665; Thacher, Biography, ii, 258.

59. Warren was elected Professor of Anatomy and Surgery on 22 November 1782; Waterhouse, Professor of the Theory and Practice of Physic on 24 December; and Dexter, Professor of Chemistry and Materia Medica on 22 May 1783. Warren and Waterhouse were inducted in an impressive ceremony on 7 October 1783. Dexter, who was unavoidably absent at this time, was inducted in a lesser ceremony on 16 October. See Harvard Corporation Records, iii, 160–163, 171, 178, 180–181, Harvard Archives, Pusey Library; Harvard Overseers’ Records, iii, 257–260, Harvard Archives, Pusey Library.

60. Martin Kaufman, American Medical Education: The Formative Years, 1765–1910 (Westport, Conn., 1976), 26.

61. Cohen, Tools, 73–80; Graustein, “Natural History,” 69–71; Harvard Corporation Records, iii, 171, Harvard Archives, Pusey Library; Hindle, Pursuit, 342–343; Moore, “Years” (article), 537–538; Moore, “Years” (thesis), 86–89.

62. Bartlett, “Progress,” 118; Beecher and Altschule, Harvard, 43; Cohen, Tools, 100–103, 113–123; Graustein, “Natural History,” 70–71; Harvard Corporation Records, iii, 307–308, iv, 472, 488, 495, 514, 535–536, 603, Harvard Archives, Pusey Library; Kett, Profession, 72–73; Lane, “Waterhouse,” 7–13; Moore, “Years” (thesis), 71–73; Morison, Centuries, 171–172; Benjamin Waterhouse, The Botanist, being the Botanical Part of A Course of Lectures on Natural History ... Together with A Discourse on the Principles of Vitality (Boston, 1811). Waterhouse gave his lectures on natural history first in 1786 and 1787 at commencement time at Brown University, where he served as an unsalaried professor of natural history and on the Board of Fellows. See J. Walter Wilson, “The First Natural History Lectures at Brown University, 1786, by Dr. Benjamin Waterhouse,” Annals of Medical History, 3rd ser., 4 (1942), 390–398.

63. See John C. Greene, “The Boston Medical Community and Emerging Science, 1780–1820,” below, 187–197.—eds.

64. Adams, Republic, 109–229; Hart, Commonwealth, iii, 341–357; Howe, Boston, 123–221; Kirker, Bulfinch’s; Marjorie Drake Ross, The Book of Boston: The Federal Period, 1775–1837 (New York, 1961); Walter Muir Whitehill, Boston: A Topographical History, 2nd ed. (Cambridge, Mass., 1968), 47–72; Winsor, Boston, iii 189–216.

65. Burrage, Society, 21–22; Lemuel Shattuck, The Vital Statistics of Boston (Philadelphia, 1841), xii–xvii; Winsor, Boston, iii, 168, fn. 2.

66. See Appendix II.

67. See Appendix II.

68. They were William Spooner, who received his M.D. from Edinburgh, and John Clark vi, who studied midwifery in London. Charles Williams Windship received his M.D. from Glasgow in 1797, but does not appear to have practiced in Boston in or before 1798.

69. They were: Samuel Brown; Nahum Fay; John Fleet, Jr.; William Dix; and William Ingalls. Brown, who had a tragically short career, dying in 1805, won the Humane Society prize for his excellent account of the Boston yellow-fever epidemic of 1789. Fleet was one of the first two graduates of the Harvard Medical Institution and was later appointed its first assistant (to John Warren in 1793). He also was the first consulting physician to the Boston Dispensary as well as recording secretary and librarian of the Massachusetts Medical Society. Ingalls became a distinguished professor of anatomy and surgery at the Brown medical school.

70. Harvard Corporation Records, iii, 358–359, 361, Harvard Archives, Pusey Library; Samuel Eliot Morison, “Dr. Amos Windship (1745–1813, H.C. 1771),” Colonial Society of Massachusetts Publications, 25 (1922–1924), 141–171; Shipton, Sibley’s, xvii, 673–679.

71. Beecher and Altschule, Harvard, 34; Burrage, Society, 19; Harrington, Harvard, I, 275; Harvard Corporation Records, III, 186, 191–193, 195, 236, Harvard Archives, Pusey Library; Memorial of the President and Fellows to the General Court, 5 February 1784, State House Archives, House File No. 1405; Moore, “Years” (article), 555–556; Morison, Centuries, 171; John Warren to Overseers of the Poor of the Town of Boston (tentatively dated 1789, should be dated 1784), Warren Papers, iii (1786–1795), Massachusetts Historical Society.

72. Bartlett, “Progress,” 113, 118–119; Burrage, Society, 51–52, 54, 303–306, 369; Eliot, “Account,” 183–184; Handlin, Commonwealth, 97, 208–209; Harvard Corporation Records, iii, 155–159, 215–217, 223–224, 426, Harvard Archives, Pusey Library; Hindle, Pursuit, 291; Kett, Profession, 14–15, 24, 72; Massachusetts Medical Society Documents, Miscellaneous, I, Countway Library, Harvard Medical School; Moore, “Years” (thesis), 100–102; Warren, John Warren, 285–287.

73. Handlin, Commonwealth, 129.

74. See the letter from Lloyd’s son, James, to James Thacher, dated 16 September 1829, inserted into a volume of Thacher’s American Medical Biography, inscribed to Dr. Edward Reynolds and now in the Countway Library, Harvard Medical School.

75. John Warren, Lectures on Anatomy, 1783–1812, Countway Library, Harvard Medical School.

76. There is a notebook in the Countway Library, Harvard Medical School, entitled “Theory and Practice of Midwifery.” There is no indication as to who the author or owner was, but it may well have been John Clark vi. It consists of a rather extensive course of thirty-six well-organized but simplified (as compared to those of the London teachers of obstetrics) lectures on midwifery such as would have been very useful to the type of medical student then in Boston.

77. The first two dispensaries were founded in Philadelphia in 1786 and New York in 1790. The Boston Dispensary was opened in 1796 and incorporated in 1801. See Bartlett, “Progress,” 127; Blake, Public Heallh, 239; Columbian Centinel, 14–21 December 1796; Leonard K. Eaton, Early New England Hospitals, 1790–1833 (Ann Arbor, Mich., 1957), 21–22; [William R. Lawrence], A History of the Boston Dispensary By One of the Board of Managers (Boston, 1859), 1–48; Warren, John Warren, 236.

78. Blake, Public Health, 166–167, 229.

79. Bartlett, “Progress,” 123–124; Blake, Waterhouse, 46–47; Blake, Public Health, 181–182; Boston Records Commissioners’ Reports, 35, 133–134; James Jackson Putnam, A Memoir of Dr. Jackson ... (Boston, 1906), 228–229; “Report of the Board of Health, December 16, 1802,” Boston Medical and Surgical Journal, 145 (1901), 445; Warren, John Warren, 404–406.

80. Bartlett, “Progress,” 124; Blake, Waterhouse, 64; Columbian Centinel, 22 December 1802.

81. Bartlett, “Progress,” 113–114; Burrage, Society, 58–59, 68–74, 418–419; Kett, Profession, 15; Putnam, Jackson, 244–246.

* Dr. Brock took her B.A. and M.A. in Natural Sciences, and her Ph.D. in Structural Materials in Animals, at Cambridge University. Her teaching and research at the University of Glasgow, where she is in the Department of the History of Science, span modern zoology and the life and work of James Douglas and his pupil William Hunter.

1. Cotton Mather, Magnalia Christi Americana (London, 1702), Book i, ch. ii, 7.

2. F.R. Packard, The History of Medicine in the United States, 2 v. (New York, 1931), i, 3–4

3. Francis Bacon, Novum Organum, Book ii, aphorism 52. (1620; from the translation by Joseph Devey, 1853).

4. Charles Webster, The Great Instauration: Science, Medicine and Reform 1626–1660 (London, 1975).

5. New Englands First Fruits (1643), quoted from S. E. Morison, The Intellectual Life of Colonial New England (New York, 1956), 31.

6. Irene Parker, Dissenting Academies in England (Cambridge, 1914).

7. S. E. Morison, “Charles Morton’s Compendium Physicae,” Colonial Society of Massachusetts Publications, 33 (1940), 117.

8. Albert Matthews, “Comenius and Harvard College,” Colonial Society of Massachusetts Publications, 21 (1919), 146–190.

9. Catalogus Librorum Bibliothecae Collegij Harvardini Quod est Cantabrigiae in Nova Anglia (Boston, 1723).

10. Boston Post-Boy and Advertiser, 30 January 1764.

11. Josiah Quincy, History of Harvard University, 2 v. (Cambridge, Mass., 1840), ii, 480–482.

12. Idem; Oliver Letterbook, ii, Andrew Oliver to Peter Oliver, Boston, 20 August 1770, Massachusetts Historical Society.

13. R. S. Wilkinson, “The Alchemical Library of John Winthrop Junior (1606–1676), and His Descendants in Colonial America,” Ambix, 2 (1963), 33–51.

14. J. H. Tuttle, “The Libraries of the Mathers,” Proceedings of the American Antiquarian Society, 20 (1910), 269–356.

15. G. E. Littlefield, Early Boston Booksellers (Boston, 1900).

16. Silvester Gardiner, uncatalogued papers, Countway Medical Library, Boston.

17. John Hartshorn, Diary (1752–1756), Countway Medical Library, Boston.

18. Samuel Adams, Diary (1769), New York Public Library.

19. Francisco Guerra, American Medical Bibliography, 1639–1783 (New York, 1962).

20. Silvester Gardiner, uncatalogued papers, Countway Medical Library, Boston. An unsigned letter to Captain Kirkwood, 15 November 1755, asking for a wooden leg to be procured in London.

21. See the Appendix.

22. For the extent of bleeding, purging, and other remedies, see J. Worth Estes, “Therapeutic Practice in Colonial New England,” below, 289–383.—eds.

23. Cotton Mather, The Angel of Bethesda. ms at the American Antiquarian Society, Worcester, Massachusetts, edited by G. W. Jones and published by American Antiquarian Society and Barre Publishers, Worcester, Mass. (1972).

24. Carl Bridenbaugh, Cities in the Wilderness (New York, 1955), 88; Nathaniel B. Shurtleff, Records of the Governor and Company of the Massachusetts Bay in New England, 12 v. (Boston, 1853), ii, 278–279.

25. Sir George Clark, A History of the Royal College of Physicians of London, 2 v. (Oxford, 1966).

26. Charles Webster, The Great Instauration: Science, Medicine and Reform 1626–1660 (London, 1975).

27. J. Woodward, To Do the Sick No Harm (London, 1974).

28. C. Bridenbaugh, Cities in Revolt (New York, 1955), 5; B. B. Mitchell and P. Deane, Abstract of British Historical Statistics (Cambridge, 1962).

29. For a detailed review of medical charity, see Douglas Lamar Jones, “Charity, Medical Charity, and Dependency in Eighteenth-Century Essex County, Massachusetts,” below, 199–213.—eds.

30. Josiah Bartlett, “A Dissertation on the Progress of Medical Science in the Commonwealth of Massachusetts,” Communications of the Medical Society of Massachusetts, 3 (1810), 240.

31. P.M. Rattansi, “Paracelsus and the Puritan Revolution,” Ambix, 2 (1963), 23–32.

32. G. H. Turnbull, “George Stark, Philosopher by Fire,” Colonial Society of Massachusetts Publications, 38 (1949), 219–251; R. S. Wilkinson, “George Starkey, Physician and Alchemist,” Ambix, 2 (1963), 121–152.

33. Boston Gazette, 19 June 1744.

34. R. S. Wilkinson, “New England’s Last Alchemists,” Ambix, 10 (1962), 128–138.

35. A.J. B. Gilsdorf, “The Puritan Apocalypse: New England Eschatology in the Seventeenth Century” (Ph.D. thesis, Yale University, 1965).

* Dr. Warden earned his B.A., M.A., and Ph.D. degrees in History at Yale University. A Lecturer at Boston University, he is especially interested in the development of history curricula in schools and in colonial legal history. He directs the activities of the Cambridge Historical Society and is the author of Boston, 1689–1776, published in 1970.

1. See Anthony Giddens, Capitalism and Modern Social Theory: An Analysis of the Writings of Marx, Durkheim and Max Weber (Cambridge, Eng., 1971), 101–102, 158–160, 203–204, 234–238.

2. See David D. Hall, The Faithful Shepherd: A History of the New England Ministry in the Seventeenth Century (Chapel Hill, N.C., 1972).

3. See Charles Warren, A History of the American Bar (Boston, 1911), and Anton-Hermann Chroust, The Rise of the Legal Profession in America (Norman, Okla., 1965).

4. See Neil R. Harris, The Artist in American Society, 1790–1860 (New York, 1966).

5. See Brooke R. Hindle, The Pursuit of Science in Revolutionary America, 1735–1789(Chapel Hill, N.C., 1956), and Raymond P. Stearns, Science in the British Colonies of America (New York, 1970).

6. For early attempts at corporate organization in other colonies, see Sidney Shindell, The Law in Medical Practice (Pittsburgh, Pa., 1966), 3–4.

7. For resistance to corporate privileges, see G. B. Warden, Boston, 1689–1776 (Boston, 1970), 102–126. During discussion, the question arose about the documentation for my argument that the medical profession did not develop in colonial Boston. There is none, and my inferences are based on the absence of such documentation in the valuable work of other scholars and in my own extensive research in the Boston newspapers, town meeting reports, General Court records, and manuscript collections of the Massachusetts Historical Society, State Archives, Boston Public Library, and Suffolk County Court House. The professional consciousness of the town’s physicians was so minimal that, to the best of my knowledge, there was never even any demand for medical organization, as there was for the clergy, merchants, and lawyers. For a differing view, and for a discussion of the later organization of Boston’s physicians as a professional association, see Philip Cash’s paper, above, 69–100.

8. See C. H. S. Fifoot, History and Sources of the Common Law: Tort and Contract (London, 1949), 157–158. During the discussion at the conference, Eric Christianson confirmed the extensive number of court cases against doctors in the legal records he has examined.

9. See Warden, Boston, 102–104, 127–129.

10. See Josiah Quincy, Jr., Reports of Cases Argued and Adjudged in the Superior Court of Judicature of the Province of Massachusetts Bay, between 1761 and 1772, ed. Samuel M. Quincy (Boston, 1865), 224–226.

11. See John B. Blake, Public Health in the Town of Boston, 1630–1822 (Cambridge, Mass., 1959).

The Medical Profession in Colonial Boston 153

12. For data on obstetrical deliveries by physicians in Boston, see J. Worth Estes, “Therapeutic Practice in Colonial New England,” below, 289–383.—eds.

13. See Perry Miller, The New England Mind: From Colony to Province (Cambridge, Mass., 1953), 345–366.

14. See Edmund S. Morgan, The Challenge of the American Revolution (New York, 1976), 88–95.

15. See Warden, Boston, 214–217.

* After earning his A.B. in History at Dickinson College, Dr. Bell took his A.M. and Ph.D. in History at the University of Pennsylvania, where he wrote his dissertation under the direction of Richard H. Shryock. Now the Executive Officer and Librarian of the American Philosophical Society at Philadelphia, he has made many contributions to colonial medical history, including John Morgan: Continental Doctor (1965), and The Colonial Physician and Other Essays (1975).

1. Andrew Burnaby, Travels through the Middle Settlements in North-America (2nd ed., London, 1775; Ithaca, N.Y., n.d.), 53–54; Robert Treat Paine, Diary, Sept.–Nov. 1751; Paine to Joseph Palmer and Richard Cranch, 26 Sept. 1751, Paine Papers (Massachusetts Historical Society); John Adams, Diary and Autobiography, ed L. H. Butterfield and others (Cambridge, Mass., 1961), II, 116, 150.

2. Daniel Coxe to Benjamin Rush, 16 May 1791, Rush mss, xxvii, 11 (Library Company of Philadelphia); Walter Charming to Benjamin Smith Barton, 29 Sept. 1811, Barton Papers (American Philosophical Society); Thomas Jefferson to Rush, 13 Oct. 1808, facsimile in Martin Meyerson, Gladly Learn and Gladly Teach (Philadelphia, 1978), 51. Jefferson expressed the same opinion in similar terms to Dr. Barton, 22 June 1807 (Boston Public Library). The records of the Pennsylvania Hospital, 1795–1820, show four or five English medical students enrolled there, in addition to a number from the West Indies and a few from Canada.

3. John F. Fulton and Elizabeth H. Thomson, Benjamin Silliman, 1779–1864: Pathfinder in American Science (New York, 1947), 23–32, 95–100; Harold J. Burr, “Jonathan Knight and the Founding of the Yale School of Medicine,” Yale Journal of Biology and Medicine, 1 (1929), 327–343.

4. Thomas Cooper, An Address delivered before the Medical Board of S. Carolina, at Columbia, December, 1821 (Columbia, S.C., 1821), 4. Cooper considered the professors of the University of Pennsylvania Medical School, Dr. Physick excepted, as undistinguished in abilities and undignified in professional conduct.

5. Population figures are conveniently collected in Evarts B. Greene and Virginia D. Harrington, American Population before the Federal Census of 1790 (New York, 1932). On the comparative growth of the cities in the colonial period see Carl Bridenbaugh, Cities in Revolt: Urban Life in America, 1743–1776 (New York, 1955).

6. Whitfield J. Bell, Jr., John Morgan, Continental Doctor (Philadelphia, 1965), 22–23.

7. On some of those mentioned here see Kenneth and Anna M. Roberts, trans. and eds., Moreau de St. Méry’s American Journey, 1793–1798 (New York, 1947).

8. Dr. Samuel A. Green, “Medicine in Boston,” in Justin Winsor, ed., The Memorial History of Boston,... 1630–1880 (Boston, 1883), iv, 527–549; J. Thomas Scharf and Thompson Westcott, History of Philadelphia (Philadelphia, 1884), II, 1578–1685; Leonard K. Eaton, “Medicine in Philadelphia and Boston, 1805–1830,” Pennsylvania Magazine of History and Biography, 75 (1951), 66–75.

9. Joseph Carson, A History of the Medical Department of the University of Pennsylvania (Philadelphia, 1869), 52ff.

10. William Cullen to Benjamin Rush, 16 Oct. 1784, Rush mss, xxiv, 56 (Library Company of Philadelphia). Cullen had written John Morgan, 18 September 1768, that the Philadelphia school had “a better Chance for transmitting what can or should pass to Posterity than any College on this Side of the Water.” Ibid., 54.

11. John Morgan to John Warren, 21 Nov. 1776, in Edward Warren, Life of John Warren, M.D. (Boston, 1874), 128; James E. Gibson, Dr. Bodo Otto and the Medical Background of the American Revolution (Springfield, Ill., 1937), 260–261.

12. George W. Corner, Two Centuries of Medicine: A History of the School of Medicine, University of Pennsylvania (Philadelphia, 1965).

13. Edward Warren, John Warren, 225–227, et passim; Benjamin Rush to Warren, 12 Oct. 1782, in L. H. Butterfield, ed., Letters of Benjamin Rush (Princeton, 1951), I, 288–289; Henry K. Beecher and Mark D. Altschule, Medicine at Harvard: The First Three Hundred Years (Hanover, N.H., 1977), 29–31.

14. Winsor, Memorial History of Boston, IV, 26.

15. Pennsylvania Gazette, 11 Jan. 1770, quoted in Journal of the History of Medicine and Allied Sciences, 23 (1968), 108–110.

16. Warren, John Warren, 26; Albert Matthews, “Notes on Early Autopsies and Anatomical Lectures,” Colonial Society of Massachusetts Publications, 19 (1916–1917), 273–290.

17. Bell, Morgan, 137–140; Bell, “For Mutual Improvement in the Healing Art: Philadelphia Medical Societies of the 18th Century,” Journal of the American Medical Association, 216 (1971), 125–129.

18. Walter L. Burrage, A History of the Massachusetts Medical Society... 1781–1922 (privately printed, 1923), 16–21, 37–41, 77–81. George Hayward, then a student in Philadelphia, in a letter to John C. Warren, 28 Feb. 1812 (Warren Papers, viii, Massachusetts Historical Society), rejoiced in the defeat of efforts to establish a college of physicians in Massachusetts.

19. See Richard D. Brown, “The Healing Arts in Colonial and Revolutionary Massachusetts,” above, 35–47; Eric H. Christianson, “The Medical Practitioners of Massachusetts, 1630–1800,” above, 49–67; and Philip Cash, “The Professionalization of Boston Medicine, 1760–1803,” above, 69–100.—eds.

20. Burrage, Massachusetts Medical Society, 302–308.

21. Herbert Thoms, “The Medical Institution of Yale College and the Connecticut State Medical Society,” Connecticut Medicine, 24 (1960), 546–551.

22. Josiah Bartlett concluded his excellent historical Dissertation on the Progress of Medical Science, in the Commonwealth of Massachusetts (Boston, 1810) with an appeal for the removal of the medical school to Boston.

23. N. I. Bowditch, A History of the Massachusetts General Hospital (Boston, 1851), 3–9. See also the address of the medical professors, 5 Sept. 1810, in which similar views are expressed. A copy is in Warren Papers, vii, 2.

24. James Jackson, A Eulogy on the Character of John Warren, M.D. (Boston, 1815), 29.

25. George E. Ellis, Memoir of Jacob Bigelow, M.D., LL.D. (Cambridge, Mass., 1880), 15–16.

26. Henry R. Viets, A Brief History of Medicine in Massachusetts (Boston, 1930), 28.

27. Clifford K. Shipton, Biographical Sketches of Those Who Attended Harvard College [Sibley’s Harvard Graduates] (Boston, 1968), xiv, 551–552.

28. Whitfield J. Bell, Jr., “Portrait of the Colonial Physician,” Bulletin of the History of Medicine, 44 (1970), 504–505.

29. R. W. Innes Smith, English-Speaking Students of Medicine at the University of Leiden (Edinburgh, 1932), passim.

30. J. Rendall, “The Influence of the Edinburgh Medical School on America in the Eighteenth Century,” in R. G. W. Anderson and A. D. C. Simpson, eds., The Early Years of the Edinburgh Medical School (Edinburgh, 1976), 95–123. Henry Lloyd generously supported the foreign medical studies of his son James, 1750–1752. The family reckoned that the reputation he would gain thereby was worth seven to ten years of practice. Papers of the Lloyd Family, I (New-York Historical Society Collections, 69 [1926], 413, et passim).

31. “Dr. Warren was probably more self-taught than any man, who has undertaken a similar office, within the last two centuries. He had indeed the books of anatomists before him; but he had not like other great teachers of our day, in this country as well as in Europe, had the benefit of personal instruction from any of the great masters in the science” (Jackson, Eulogy on Warren, 15). But, Jackson continued, his mind on current developments in Boston, a medical education confined to the walls of a university was always deficient. “A medical school can never flourish except in a large town.... In 1810 he [Warren], with his colleagues, effected the extension of the medical lectures to this town [from Cambridge to Boston]; and since that time the correctness of his judgement has been abundantly demonstrated by the increased usefulness and increased prosperity of the Institution” (ibid., 16).

32. Whitfield J. Bell, Jr., “James Hutchinson (1752–1793): Letters from an American Student in London,” College of Physicians of Philadelphia, Transactions & Studies, 4th ser., 34 (1966), 20–25.

33. Also see C. Helen Brock, “The Influence of Europe on Colonial Massachusetts Medicine,” and its Appendix, above, 101–143.—eds.

34. Betsy C. Corner, William Shippen, Jr., Pioneer in American Medical Education (Philadelphia, 1951), 25ff., 73; Whitfield J. Bell, Jr., “Philadelphia Medical Students in Europe, 1750–1800,” Pennsylvania Magazine of History and Biography, 67 (1943), 17–18.

35. James Hall to Benjamin Rush, 4 March 1784, in W. S. W. Ruschenberger, An Account of the Institution and Progress of the College of Physicians of Philadelphia . . . from January, 1787 (Philadelphia, 1887), 17.

36. Walter Channing to George C. Shattuck, 20 April 1811, Shattuck Papers, III.

37. Appendix I to Philip Cash, “The Professionalization of Boston Medicine, 1760–1803,” above, 69–100. Walter Channing summarized the difference between Edinburgh and London in bold and certainly exaggerated terms. “In Edinburgh & throughout Scotland medicine is the grand object of pursuit. It is taught upon the most liberal plan. It is considered the most respectable, & far the most important branch of the art, & looks upon surgery as upon the apothecary as a necessary appendage to its system. But in London the thing is quite reversed, & I should think throughout England, as there is no surer way to eminence than the compilation or composition of a work on surgery, ornamented with some pretty pictures. Mr. Cooper is considered as knowing nothing of medicine, & a friend of mine, a very clever man heard him declare at table that he doubted how far medicine was a blessing to society.” Happily, Channing continued, in America a practitioner was not compelled to choose one specialty or the other. Medicine and surgery were “united, & we need not degrade one, to increase the reputation of the other.” Channing to George C. Shattuck, 20 April 1811, Shattuck Papers, III.

38. Burrage, Massachusetts Medical Society, 115.

39. Ebenezer Alden to George C. Shattuck, 19 Jan. 1812, Shattuck Papers, III. Dr. Henry I. Bowditch recorded Dr. Jacob Bigelow’s recollections (in advanced old age) of his Philadelphia professors. Rush and Wistar were kindly, the latter especially was warmhearted; both “received” the students. Physick, on the contrary, was “a savage,” who never invited them to his house and would not associate with them. Barton was “egotistical, a bad reader and speaker.” Rush, “enthusiastic and eloquent,” was a great believer in medicine and drugs, an “ultra practitioner,” who used to admonish his students, “we can have no reliance on nature, gentlemen. We must turn her out of doors in our practice, and substitute for her efficient art. The vis medicatrix naturae which Cullen taught is a delusion.” Vincent Y. Bowditch, Life and Correspondence of Henry Ingersoll Bowditch (Boston, 1902), II, 285.

40. Nathan Smith to George C. Shattuck, 22 Jan. [1807] (typescript), Shattuck Papers, I.

41. Ephraim Eliot, “Account of the Physicians of Boston,” Massachusetts Historical Society Proceedings, Ser. 1, 7 (1863–1864), 179, 180.

42. For the incidence of bleeding in two Boston practices see Table IV in J. Worth Estes, “Therapeutic Practice in Colonial New England,” below, 289–383.—eds.

43. Burrage, Massachusetts Medical Society, 26.

44. Oliver W. Holmes, “Additional Memoranda” [to Green’s “Medicine in Boston”] in Winsor, Memorial History of Boston, iV, 557; John Adems Paxton, comp., Philadelphia Directory and Register, for 1818; Boston Directory... (Boston, 1816). Bleeding was practiced little, if at all, in cases reported in the Boston Medical Commentaries, II, 39–40, 111ff., 145, 462–475. Holmes speaks with some surprise of a Boston physician whom he consulted in 1867, who carried two lancets with him at all times—he had never given up their use. Holmes, “Scholastic and Bedside Teaching,” in Medical Essays (Boston, 1899), 295.

45. General Alumni Catalogue of the University of Pennsylvania, 1922; Thomas F. Harrington, The Harvard Medical School (New York, 1905), III, 1449ff.

46. Joseph I. Waring, A History of Medicine in South Carolina, 1825–1900 (Columbia, S.C., 1967), 72.

47. Walter Channing to George C. Shattuck, [August 1808], Shattuck Papers, II; Channing to Benjamin S. Barton, 20 March [no year], Barton Papers.

48. W. Welch to George C. Shattuck, 31 May 1811, Shattuck Papers, III.

49. George Hayward to Benjamin S. Barton, 10 Sept. 1814, Barton Papers; Hayward to John C. Warren, 28 Nov. 1811, 28 Feb. 1812, Warren Papers, vii, viii.

50. Only one New Englander is listed on the roll of Rush’s “regiment of prentices,” as he called them, 1770–1812. James E. Gibson, “Benjamin Rush’s Apprenticed Students,” College of Physicians of Philadelphia, Transactions & Studies, 4th ser., 14 (1946–1947), 127–132.

51. Ellis, Memoir of Jacob Bigelow, 15–16; George C. Shattuck to Benjamin S. Barton, 9 Aug. 1807 (copy), Shattuck papers, I; Daniel Oliver to Barton, 20 May 1811, Walter Channing to Barton, 20 March [no year], Barton Papers.

52. Roswell Shurtleff to George C. Shattuck, 17 Dec. 1806; Shattuck to Shurtleff, 11 Jan. 1807, Shattuck Papers, I.

53. Shattuck to Shurlteff, 10 Nov. 1806, ibid.

54. Amos Twitchell to George C. Shattuck, 20 May 1808, Shattuck Papers, II; George Hayward to John C. Warren, 28 Nov. 1811, Thomas Foster to Warren, 14 Dec. 1811, Warren Papers, viii.

55. Benjamin Lynde Oliver to Benjamin Rush, 5 May 1808, Rush mss, xii, 57.

56. Leonard K. Eaton, “Charles Bulfinch and the Massachusetts General Hospital,” Isis, 41 (1950), 8–11.

57. Nathan Ryno Smith to George C. Shattuck, 21 Jan. 1823. A transcript of this letter, without reference to the location of the original, was given me by Miss Elizabeth H. Thomson, Department of the History of Medicine, Yale University.

* After studying Political Science at the University of South Dakota, Dr. Greene earned his M.A. and Ph.D. in History at Harvard, and he is now Professor of History at the University of Connecticut at Storrs. The author of two books on the history of evolutionary biology, he has also published, with John G. Burke, The Science of Minerals in the Age of Jefferson (1978), and is now completing American Science in the Age of Jefferson.

1. Joseph I. Waring, A History of Medicine in South Carolina, 1670–1825 (Columbia, S.C., 1964); Brooke Hindle, The Pursuit of Science in Revolutionary America, 1735–1789 (Chapel Hill, N.C., 1956), chs. 2–3; George E. Gifford, Jr., “Charleston Physician Naturalists,” Bulletin of the History of Medicine, 49 (1975), 556–574. The role of physicians in early American mineralogy is apparent in John C. Greene and John G. Burke, The Science of Minerals in the Age of Jefferson, Transactions of the American Philosophical Society, 68 (1978), part iv.

2. George W. Corner, Two Centuries of Medicine: A History of the School of Medicine, University of Pennsylvania (Philadelphia and Montreal, 1965); Whitfield J. Bell, Jr., The Colonial Physician and Other Essays (New York, 1975); George Gaylord Simpson, “The Beginnings of Vertebrate Paleontology in North America,” Proceedings of the American Philosophical Society, 86 (1943), 130–188; George E. Gifford, Jr., “Medicine and Natural History—Crosscurrents in Philadelphia in the Nineteenth Century,” Transactions & Studies of the College of Physicians of Philadelphia 4th ser., 45 (1978), 139–149.

3. Courtney R. Hall, A Scientist of the Early American Republic, Samuel Latham Mitchill 1764–1831 (New York, 1934); Christine Chapman Robbins, David Hosack, Citizen of New York (Memoirs of the American Philosophical Society, 62, 1964).

4. I. Bernard Cohen, Some Early Tools of American Science... (Cambridge, Mass., 1950); Jeanette E. Graustein, “Natural History at Harvard College, 1788–1842,” Proceedings of the Cambridge Historical Society, 38 (1959–60), 69–86; Henry R. Viets, A Brief History of Medicine in Massachusetts (Boston and New York, 1930), chs. 4–5; Edward Warren, The Life of John Warren, M.D.... (Boston, 1874).

5. Quoted in George P. Fisher, Life of Benjamin Silliman, M.D.. LL.D.... Chiefly from his Manuscript Reminiscences, Diaries, and Correspondence, 2 v. (New York, 1866), I, 19.

6. Benjamin Waterhouse, autobiographical ms at the Francis A. Countway Library of Medicine, Harvard Medical School. See also James J. Abraham, Lettsom: His Life, Times, Friends and Descendants (London, 1933), 360–361; Lloyd E. Hawes, Benjamin Waterhouse, M.D., First Professor of the Theory and Practice of Physic at Harvard and Introducer of Cowpox Vaccination into America... (Boston, 1974).

7. Sidney Willard, Memories of Youth and Manhood, 2 v. (Cambridge, Mass., 1855), I, 169.

8. Edward Warren, The Life of John Collins Warren, M.D. Compiled Chiefly from his Autobiography and Journals, 2 v. (Boston, 1860); James Jackson Putnam, A Memoir of Dr. James Jackson With Sketches of His Father Hon. Jonathan Jackson, and His Brothers... (Boston and New York, 1905); Walter L. Burrage, A History of the Massachusetts Medical Society with Brief Biographies of the Founders and Chief Officers, 1781–1922 (Norwood, Mass., 1923).

9. John Gorham to Benjamin Silliman, Boston, 20 Nov. 1809, and 28 Sept. 1810, Silliman Correspondence, Beinecke Library, Yale University. See also James Jackson, An Address Delivered at the Funeral of John Gorham, M.D.... (Boston, 1829). There is a good account of Gorham in Cohen, Some Early Tools of American Science ..., ch. 4.

10. John Gorham to Benjamin Silliman, Boston, 20 June 1811, Silliman Correspondence, Beinecke Library, Yale University.

11. Ibid.

12. Some Account of the Medical School in Boston, and of the Massachusetts General Hospital (Boston, 1824).

13. Warren, Life of John Collins Warren, I, 11, quoting J. C. Warren’s autobiographical notes.

14. John Collins Warren, A Comparative View of the Sensorial and Nervous Systems in Men and Animals (Boston, 1822). Appendix H consists of an “Account of the Crania of some of the Aborigines of the United States.” Alěs Hrdlička, in his Physical Anthropology: Its Scope and Aims, Its History and Present Status in the United States (Philadelphia, 1919), 31, describes Warren’s “Account” as being “remarkable for the systematic, technical descriptions of the specimens.”

15. George E. Ellis, Memoir of Jacob Bigelow, M.D., LL.D., Proceedings of the Massachusetts Historical Society, 17 (1879–1880), 383–467.I am indebted to RichardJ. Wolfe for letting me see a manuscript copy of his Jacob Bigelow’s “American Medical Botany,” 1817–1821 (Boston, 1979).

16. “Museum of Natural History,” New England Journal of Medicine and Surgery, 5 (1816), 189–191; see also 9 (1820), 311–313. See also Thomas T. Bouvé, Historical Sketch of the Boston Society of Natural History; With a Notice of the Linnaean Society, Which Preceded It, Anniversary Memoirs of the Boston Society of Natural History... 1830–1880 (Boston, 1880), 4–14.

* Dr. Jones earned his B.A. in History at Duke University. After studying Law at the University of Texas, he obtained his MA. in History there, and his Ph.D., in the History of American Civilization, at Brandeis University. Now Assistant Professor of History at Tufts University, he has just completed a fellowship at the Charles Warren Center for Studies in American History at Harvard. He has published several articles on the history of the law, poverty, and charity in colonial America.

1. William Bentley, The Diary of William Bentley, 2 vols. (Gloucester, Mass., 1962), II, 88.

2. These changes in Essex County are discussed in Douglas Lamar Jones, “Geographic Mobility and Society in Eighteenth-Century Essex County, Massachusetts” (Ph.D. dissertation, Brandeis University, 1975); also, see Philip J. Greven, Jr., Four Generations: Population, Land, and Family in Colonial Andover, Massachusetts (Ithaca, 1970). For a more focused discussion of poverty in Essex County, see Douglas Lamar Jones, “The Strolling Poor: Transiency in Eighteenth-Century Massachusetts,” Journal of Social History, 8 (1975), 28–54.

3. David J. Rothman, The Discovery of the Asylum: Social Order and Disorder in the New Republic (Boston, 1971); Gerald Grob, Mental Institutions in America (New York, 1973).

4. Rothman, Asylum, 3–6. One should also consult Albert Deutsch, “The Sick Poor in Colonial Times,” American Historical Review, 46 (1940–1941), 560–579.

5. For a fuller exposition of the religious concept of “affliction” and Puritan ideas of poverty and wealth, see Stephen Foster, Their Solitary Way: The Puritan Social Ethic in the First Century of Settlement in New England (New Haven, 1971), 124–129; and chapter five generally.

6. The Reverend William Bentley, Sermon No. 20 [undated], [p. 1]. The manuscript sermons of Bentley are located in the Archives of Tufts University, Medford, Massachusetts.

7. Bentley, Sermon No. 20, [p. 7].

8. Foster, Their Solitary Way, 134–144.

9. Jones, “The Strolling Poor,” 42–48; also see Hendrik Hartog, “The Public Law of a County Court; Judicial Government in Eighteenth Century Massachusetts,” American Journal of Legal History, 20 (1976), 282–329.

10. Petition and Acct. of Selectmen of Andover Abt Joshua Barker of Methuen, File Papers, 1761, Essex County Court of General Sessions of the Peace. Hereafter, references to the Essex Sessions Court will be only to the File Papers or to the Record Books. These materials are located in the Clerk’s Office, Salem Courthouse, Salem, Massachusetts.

11. Newbury v. Gloucester, File Papers, 1763.

12. Petition of the Selectmen of the Town of Marblehead, File Papers, 1752.

13. E. A. Holyoke, Leger-Book [sic], [vii], [No. ii], 1181, 1125, Holyoke Papers, Essex Institute, Salem, Massachusetts.

14. Petition of Andover for H. Long, File Papers, 1757.

15. Petitions of Tho. Rowell Etc. for Mary Flanders, File Papers, 1759; Petition of Town of Rowley, File Papers, 1769.

16. On these points, see Hartog, “The Public Law of a County Court,” 303–308.

17. Case of Mary Harris, Record Book, December Term, 1764, 37.

18. Massachusetts Acts and Resolves, ch. 17, 1758–1759, 178–179. On midwifery in early America, see Catherine M. Scholten, “ ‘On the Importance of the Obstetrick Art’: Changing Customs of Childbirth in America, 1760–1825,” William and Mary Quarterly, 34 (1977), 426–445; and Charlotte Gregg Borst, “Midwives in Early New England, 1620–1820: From Healer and Community Authority to Quack and Outsider” (M.A. thesis, Tufts University, 1977).

19. Case of Joan Reed, Record Book, February Term, 1717.

20. Petition of Selectmen of Haverhill, File Papers, 1765; Wenham Town Records (Wenham, Mass., 1930), III, 99.

21. For more general discussions of the categories of physicians and medical practitioners in early America, see Richard Harrison Shryock, Medicine and Society in America, 1660–1860 (Ithaca, 1962), 1–43; and Whitfield J. Bell, “Medical Practice in Colonial America,” Bulletin of the History of Medicine, 31 (1957), 442–453.

22. Among numerous examples, see the Case of Sarah Silver, File Papers, 1758.

23. Newbury v. Gloucester, File Papers, 1763.

24. Petition... of Andover Abt Joshua Barker..., File Papers, 1761.

25. Quoted in Henry Follansbee Long, “The Physicians of Topsfield, with Some Account of Early Medical Practice,” Historical Collections of the Topsfield Historical Society, 16 (1911), 7; also quoted in Bell, “Medical Practice in Colonial America,” 450–451, fn. 28.

26. The Holyoke ledgers and day books are in the Holyoke Papers; Amos Spofford’s book, April 1795, is a one-volume ledger, dated 1795–1804; and Nehemiah Cleaveland left three volumes of account books and six day books. All of these manuscript materials are located in the Essex Institute, Salem, Massachusetts.

27. DAB, ix, s.v. “Holyoke, Edward Augustus.”

28. Salem Town Records, 10 May 1749. Box 4 (1748–1775), folder 1, 22. This is a handwritten copy in the Essex Institute. For Holyoke’s participation, see, ibid., 16 May 1770. Box 4 (Oct 1768 – Oct. 1770), folder 8, 786–787.

29. See John Duffy, Epidemics in Colonial America (Baton Rouge, La., 1953), 127–128, 176–177; and Shryock, Medicine and Society, 91–95.

30. Jones, “The Strolling Poor,” 45.

31. Joseph B. Felt, Annals of Salem, 2 v. (Salem, Mass., 1849), II, 400–401; Rules and Orders for the Management of the Work House ... 1749–1798, v. 14, Public Welfare Department, Salem, Mass. Located in the Essex Institute. For a useful discussion of the workhouse in Salem in the very early nineteenth century, see Anne Farnam, “Uncle Venner’s Farm: Refuge or Workhouse for Salem’s Poor?” Essex Institute Historical Collections, 109 (1973), 60–86.

32. Overseers of the Poor. Miscellaneous, 1746–1832, Essex Institute. Most of the payments from the few records which remain went to Holyoke. He may have been the official physician to the poor, but no evidence indicates that this relationship was formalized with the town selectmen. Dr. Moses Little is recorded as receiving payments from the town in 1794 and 1795.

33. The sample years examined include, with the number of sick poor visited, the following: 1756 (55); 1761 (48); 1766 (39); 1771 (43); and 1776 (301). This information is taken from Leger-Book [sic], v. i, no. ii, 156; ibid., v. ii, no. ii, 233, 358; ibid., v. iii, no. ii, 477, and v. iv, no. ii, 628; ibid., v. [iv], no. [ii], 760, and v. [v], no. [ii], 885; and v. [vii], no. [ii], 1181, 1125.

34. Low mean ages of death for both lower-class men and women in two Essex County towns, Beverly and Wenham, occurred during the eighteenth century; see Jones, “Geographic Mobility and Society,” 47–52.

35. Generally, see Shryock, Medicine and Society, 100–105. For the Salem workhouse, see “Rules and Orders for the Management of the Work House,” 870, Salem Town Records. Box 4 (Oct. 1770 – Jan. 1773), folder 9.

36. Although the sample of Cleaveland’s patients is taken from the year 1784, it can be considered comparable to Holyoke’s because each year represented the early stages of medical practice for the two physicians.

37. For the daily caseloads of physicians in neighboring southern New Hampshire, see J. Worth Estes, “Therapeutic Practice in Colonial New England,” especially Table I, below, 289–383.—eds.

38. William Barlow and David O. Powell, “James Thacher’s American Medical Biography: The Sketch of Dr. Joseph Orne of Beverly, Massachusetts,” Essex Institute Historical Collections, 114 (1978), 213–221; see especially the letter from Orne to Holyoke, 218–220.

* Dr. Wigglesworth studied Sociology as an undergraduate at Harvard, where he also earned his M.D. degree. Although his primary activity is private surgical practice, he is an Instructor in Surgery at the Tufts University School of Medicine and has been studying medical history for the past ten years because he enjoys it.

1. Russell Leigh Jackson, The Physicians of Essex County (Salem, Mass., 1948), 42.

2. Thomas Franklin Waters, Ipswich in the Massachusetts Bay Colony (Ipswich, Mass., 1905), 83.

3. See C. Helen Brock, “The Influence of Europe on Colonial Massachusetts Medicine,” and its Appendix, above, 101–143.—eds.

4. Henry R. Viets, A Brief History of Medicine in Massachusetts (Boston, 1930), 11.

5. Henry E. Sigerist, A History of Medicine, (New York, 1951), I, 207.

6. Viets, Brief History, 2.

7. L. S. Bryan, “Blood Letting in American Medicine,” Bulletin of the History of Medicine, 28 (1964), 516–529; Ralph Major, A History of Medicine (New York, 1959), 53; Guido Majno, The Healing Hand (Cambridge, Mass., 1975), 417–418.

8. Ibid., 400; Allen O. Whipple, The Story of Wound Healing and Wound Repair (Springfield, Ill., 1963), 48.

9. L. M. Zimmerman and Ilza Vietz, Great Ideas in the History of Surgery (Baltimore, 1961), 96; Viets, Brief History, 3.

10. Richard Hardway Meade, An Introduction to the History of General Surgery (Philadelphia, 1968), 156.

11. For the professional education of later practitioners, see Eric H. Christianson, “The Medical Practitioners of Massachusetts, 1630–1800,” above, 49–67; Philip Cash, “The Professionalization of Boston Medicine, 1760–1803,” above, 69–100; and C. Helen Brock, “The Influence of Europe on Colonial Massachusetts Medicine,” above, 101–143.

12. Ralph Boas and Louise Boas, Cotton Mather: Keeper of the Puritan Conscience (New York, 1928).

13. Oliver Wendell Holmes, Medical Essays, 2 v. (Boston, 1892), II, 277–286. Viets’ Brief History, 48–49.

14. Viets, Brief History, 37–38; Walter L. Burrage, A History of the Massachusetts Medical Society... 1781–1922 (Norwood, Mass., 1923), 92–94.

15. Bernard Wolf Weinberger, An Introduction to the History of Dentistry In America (St. Louis, 1948), 3.

16. James G. Mumford, A Doctor’s Table Talk (New York, 1912), 252.

17. Uncatalogued manuscript notes, Edward Augustus Holyoke Papers, Essex Institute, Salem.

18. Therapeutic trial and error seem to have been infrequent; see J. Worth Estes, “Therapeutic Practice in Colonial New England,” below, 289–383.

19. Francisco Guerra, American Medical Bibliography, 1639–1783 (New York, 1962), 462–463.

20. J. Worth Estes, Hall Jackson and the Purple Foxglove (Hanover, N.H., 1979), 5–9.

21. Burrage, Medical Society, 1. (As Professor Cash points out, the Boston doctors did not form a permanent association until after the war; see above, 69–100.—eds.)

22. Baron [Gerhard] van Swieten, The Diseases Incident to Armies with the Method of Cure (Philadelphia, 1776), 81.

23. Ibid., 81–82.

24. William Northcote, Extracts from the Marine Practice of Physic and Surgery (Philadelphia, 1776), issued with van Swieten, note 22 above, 115.

25. Ibid., 115.

26. Ibid., 116.

27. John Jones, Plain Concise Practical Remarks on the Treatment of Wounds and Fractures (Philadelphia, 1776), 5–9. The first edition had been issued in the previous year.

28. Ibid., 21–24.

29. Ibid., 25–26.

30. Ibid., 30–44, especially 41.

31. Ibid., 44–56.

32. Ibid., 56–59.

33. Ibid., 56–57

34. Massachusetts Medical Society Documents, unpublished manuscripts, Countway Library of Medicine, Boston, 11, numbers 9, 26, 32, 42.

35. John Ashurst, “Surgery Before the Days of Anesthesia,” in The Semi-Centennial of Anaesthesia (Boston, 1897), 28–29; Whipple, Wound Healing, 68.

36. Whipple, Wound Healing, 31.

37. Ibid., 32.

38. Jones, Practical Remarks, 1. For a detailed discussion of the problems in practical surgery which the introduction of anesthesia would later alleviate, see Josiah Charles Trent, “Surgical Anesthesia,” Journal of the History of Medicine and Allied Sciences, 1 (1946), 505–514.

* A student of American Literature at Middlebury College, Dr. Cassedy earned his A.M. and Ph.D. in American Civilization at Brown University. As Historian at the National Library of Medicine in Bethesda, he is Editor of the Library’s annual Bibliography of the History of Medicine. He published his Demography in Early America in 1969, and is now completing a book on Medicine, Statistics, and National Growth in Nineteenth-Century America.

1. See, for example, Tables VI through IX in J. Worth Estes, “Therapeutic Practice in Colonial New England,” below, 289–383.—eds.

2. John Southerden Burn, The History of Parish Registers in England (London, 1829); James Christie, Some Account of Parish Clerks (London, 1893); James H. Cassedy, “Medicine and the Rise of Statistics,” in Allen G. Debus, ed., Medicine in Seventeenth Century England (Berkeley, 1974), 283–312.

3. John B. Blake, “The Early History of Vital Statistics in Massachusetts,” Bulletin of the History of Medicine, 29 (1955), 46–54; Robert Gutman, Birth and Death Registration in Massachusetts 1639–1900 (New York, 1959); R. R. Kuczynski, “The Registration Laws in the Colonies of Massachusetts Bay and New Plymouth,” Journal of the American Statistical Association, 7 (1900–1901), 65–73. These state registers recorded births and deaths in place of baptisms and burials. Apart from the vital statistics registers, of course, Massachusetts colonial officials were concerned with collective mortality as a phase of political arithmetic; royal governors were regularly instructed to furnish the Board of Trade in London with information on the numbers of births and deaths.

4. Annual bills of mortality were issued in Salem starting in 1768. Boston did not make provision for regular, printed bills until 1810. See Boston News-Letter, 1704 onward; Maris A. Vinovskis, “Mortality Rates and Trends in Massachusetts before 1860,” Journal of Economic History, 32 (1972), 185–190; John B. Blake, Public Health in the Town of Boston, 1630–1822 (Cambridge, Mass., 1959), 106–107, 213–215; Cassedy, Demography, 117–147.

5. Samuel Sewall’s records of this kind of information are particularly well known. “Diary of Samuel Sewall, 1674–1729,” Collections of the Massachusetts Historical Society, 5th ser., 6 (1879). For examples of local lists of deaths that were kept by women, see Mary F. Peirce, ed., Town of Weston: Births, Deaths and Marriages 1701–1850 (Boston, 1901). See Josiah H. Benton, Jr., Early Census Making in Massachusetts 1643–1763 (Boston, 1905); and James H. Cassedy, Demography in Early America: Beginnings of the Statistical Mind 1600–1800 (Cambridge, Mass., 1969).

6. While historians sometimes refer to these journals or registers as “bills of mortality,” this terminology can and does cause confusion. In the present context, therefore, I have deliberately distinguished between the private, unpublished mortality lists of the clergyman, and the public published documents which emulated the original London bills of mortality. Unlike a few Anglican and other parishes of Philadelphia and Charleston, South Carolina, the Massachusetts churches (Congregational as well as other) apparently never published their vital records in the form of broadside bills of mortality.

7. Edmund S. Morgan, The Puritan Family (New York, 1966); Ola Elizabeth Winslow, Meetinghouse Hill 1630–1783 (New York, 1952), 99; David E. Stannard, “Death and the Puritan Child,” in his Death in America (Philadelphia, 1975), 9–29. The symbols of death which adorned eighteenth-century gravestones were often the same as those which embellished printed funeral sermons and bills of mortality. See Allen Ludwig, Graven Images: New England Stonecarving and Its Symbols 1650–1815 (Middle-town, Conn., 1966); and Margaret M. Coffin, Death in Early America (Nashville, 1976). For a discussion of some of the possibilities in quantitative studies of New England gravestones, see Edwin S. Dethlefsen, “Colonial Gravestones and Demography,” American Journal of Physical Anthropology, 31 (1969), 321–333.

8. “Diary of Samuel Sewall,” 170.

9. Among the particularly useful publications are Blake, Public Health in Boston; John Duffy, Epidemics in Colonial America (Baton Rouge, La., 1953); Ernest Caulfield, A TrueHistory of the Terrible Epidemic Vulgarly Called the Throat Distemper (New Haven, 1939); Vinovskis, “Mortality Rates and Trends in Massachusetts”; R. S. Meindl and A. C. Swedlund, “Secular Trends in Mortality in the Connecticut Valley, 17001850,” Human Biology, 49 (1977), 389–414.

10. William B. Trask, ed., “Rev. Samuel Danforth’s Records of the First Church inRoxbury, Mass.,” New England Historical and Genealogical Register, 34 (1880), 84–89, 162–166, 297–301, 359–363.

11. Isaac Backus, “Bills of Mortality (1749–1805),” unpublished manuscript at Andover Newton Theological School.

12. Thomas Prince, A Sermon occasioned by the Death of the Honourable Mary Belcher (Boston, 1736), 10–12.

13. For a discussion of these interests, see Cassedy, Demography, 111–116, 172–179.

14. Ezra Stiles, “Deaths in Newport, R.I., 1760–1764,” New England Historical and Genealogical Register, 62 (1908), 283–291, 352–363; 63 (1909), 51–58. The original manuscript of this document is in the Rhode Island Historical Society.

15. Ezra Stiles, A Funeral Sermon, Delivered Thursday, July 26, 1787 (New Haven, 1787). Stiles appended extracts and analyses from Whittelsey’s records. Jeremy Belknap, The History of New-Hampshire, 2nd ed., 3 v. (Boston, 1813), iii, 178–188.

16. The first of these periodicals, New York’s Medical Repository (v. 1, 1797–1798), included several such contributions from clergymen in its early years. Boston’s Medical and Agricultural Register did not even bother to solicit these kinds of data from doctors, but concentrated on the clergy. Ibid., I, 1806–1807, cited in Blake, Public Health in Boston, 214–215.

17. Edward Wigglesworth, "A Table shewing the Probability of the Duration, the Decrement, and the Expectation of Life, in the States of Massachusetts and New Hampshire, formed from sixty two Bills of Mortality on the files of the American Academy of Arts and Science, in the ear 1789," <i>Memoirs, American Academy of Arts and Sciences,</i> 2, parts 1-2 (1793) 131-135; American Academy of Arts and Sciences, broadside dated 10 Nov. 1785, "Sir, The American Academy. . ." (Boston 1785). For a recent analysis of the merits and shortcomings of Wigglesworth's table, see Maris A. Vinoskis, "The 1789 Life Table of Edward Wigglesworth," <i>Journal of Economic History,</i> 31 (1971), 570-590. Among other things, the Academy's 1785 questionnaire asked that annual vital statistics submittd be entered on a standard form, upon which causes of death should be listed under any of sixty-eight different suggested disease terms.

18. While it seems certain that most returns were made by clergymen, it is not now possible to verify this since the original bills collected by the Academy in the 1780’s are no longer in the Academy’s files and have not been located in other repositories. At the same time, while a great many seventeenth- and eighteenth-century mortality journals of clergymen have been located and published by historical periodicals, I have not seen any by Massachusetts physicians reproduced in such publications.

19. Edward Augustus Holyoke, “A Bill of Mortality for the town of Salem, for the year 1782,” Memoirs, American Academy of Arts and Sciences, 1 (1785), 546–550 (includes the bill for 1783); Edward A. Holyoke, “On Meteorological Observations and Bills of Mortality,” ibid., 2, part 2 (1804), 58–61; Edward Augustus Holyoke, “An Account of the Weather and of the Epidemics, at Salem, in the County of Essex, for the year 1786,” Medical Communications, Massachusetts Medical Society, 1 (1787), 17–40 (includes bill of mortality for 1786).

20. J. Worth Estes, “As Healthy a Place as Any in America’: Revolutionary Portsmouth, N.H.,” Bulletin of the History of Medicine, 50 (1976), 536–552. Josiah Bartlett did not start keeping records of the births and deaths “within the limits of his practice” in Charlestown, Massachusetts, until 1789, while Lyman Spalding did not initiate his bills of mortality for Portsmouth, New Hampshire, until 1801. Jedidiah Morse, “Topographical Account of Charlestown (Massachusetts), with Bills of Mortality, Etc., Etc.,” Medical Repository, 2 (1799), 7–12; Lyman Spalding, “Bill of Mortality for Portsmouth, New Hampshire, for a.d. 1801,” Medical Repository, 5 (1802), 354.

21. Cassedy, Demography, 117–147, 274–304.

* Dr. Gifford obtained both his B.S. and M.D. degrees at the University of Maryland, and an M.A. in the History of Science at Harvard. A practicing psychiatrist, he is also Consultant to the Historical Collections at the Countway Library and head of the section on the History of Medicine in the Department of Socio-Medical Sciences at Boston University School of Medicine. A student of the history of natural history, he edited a book on the Physician Signers of the Declaration of Independence (1976).

1. J. J. Byrne, “Medicine at Plymouth Plantation,” New England Journal of Medicine, 259 (1958), 1012–1017; H. M. Dexter, “October Meeting 1889: Catalogue of Elder Brewster’s Library,” Proceedings of the Massachusetts Historical Society, 5 (1889), 37–85.

2. T. F. Harrington, “Dr. Samuel Fuller, of Mayflower (1620), Pioneer Physician,” Bulletin of the John Hopkins Hospital, 14 (1903), 263–270; Henry R. Viets, A Brief History of Medicine in Massachusetts (Boston, 1930), 8–18, 28; James Thacher, American Medical Biography, 2 v. (Boston, 1828), I, 266–267.

3. For an excellent account of medical practice in this era, see Joseph F. Kett, The Formation of the American Medical Profession (New Haven, 1968), 1–13. For other overviews, see Richard Harrison Shryock, Medicine and Society in America, 1660–1860 (Ithaca, 1962), 1–43; Gordon W. Jones, ed., The Angel of Bethesda by Cotton Mather (Barre, Mass., 1972), xxxi–xxxv; O. T. Beall and R. H. Shryock, Cotton Mather, First Significant figure in American Medicine (Baltimore, 1954), 19–33.

4. Quoted in Richard Harrison Shryock, The Development of Modern Medicine (New York, 1947), 19.

5. Fielding H. Garrison, An Introduction to the History of Medicine, 4th ed. (1929; rpt. ed., Philadelphia, 1960), 112; Malcolm Sydney Beinfield, “The Early New England Doctor: An Adaptation to a Provincial Environment,” Yale Journal of Biology and Medicine, 15 (1942–1943), 103–104; Edward Eggleston, The Transit of Civilization, from England to America in the Seventeenth Century (Boston, 1959), 50–58.

6. For information about the “doctrine of signatures” see: Garrison, History, 205, 206, 237; C. Mettler, History of Medicine (Philadelphia, 1947), 2, 201; Ralph C. Major, A History of Medicine, 2 v. (Springfield, Ill., 1954), I, 388–390; Maurice Bear Gordon, Aesculapius Comes to the Colonies (Ventnor, N.J., 1949), 3–4; Thomas J. Pettigrew, On Superstitions Connected with the History and Practice of Medicine and Surgery (London, 1844); Arturo Castiglioni, A History of Medicine (New York, 1947), 21, 449; Byrne, “Plymouth Plantation,” see note 1; Agnes Arber, Herbals: Their Origin and Evolution (Cambridge, England, 1938), 247–263; Eleanour S. Rohde, The Old English Herbals (New York, 1922), 1, 168–169, 231; Whitehead, “Indian Medical Exhibit,” 1–26; Harvey Wickes Felter, “The Genesis of the American Materia Medica Including a Biographical Sketch of’John Josseln, Gent’,” Bulletin of the Lloyd Library, no. 26, Reproduction series no. 8 (1927), 4; Beinfield, “New England Doctor”; Scott Buchanan, The Doctrine of Signatures (New York, 1938); Encyclopaedia Britanitica (Chicago, 1952), xx, 644.

7. Quoted in Arber, Herbals, 250–251.

8. Eggleston, Transit, 57.

9. Mettler, History, 200.

10. Rembert Dodoens (1517–1585), physician to the Emperors Maximilian II and Rudolph II, is best known today as a botanist. His Crydboeck (Antwerp, 1553) was assembled with other of his writings in a huge Stirpium historiae (Antwerp, 1583), which became a model for Gerard’s Herball, according to Castiglioni, Medicine, 441. Other references to Dodoens are in Arber, Herbals, 70, 76, 81, 83–86, 91, 122–126, 155, 162, 174, 176, 227–229, 232–234, 239, 255, 266, 277–280; Rohde, Herbals, 58, 83, 86, 93–98, 100, 103–104, 211–212, 230. According to Viets, Massachusetts, 21, “Gerard took most of his material from the great Latin herball of Dodoens, claiming it to be a work of his own.”

11. E. Kremers, “American Pharmaceutical Documents, 1643 to 1780,” Badger Pharmacist, no. 15 (1937). The original 1643 letter of Dr. Stafford is in the Boston Medical Library Collections, Countway Library.

12. Oliver Wendell Holmes, Medical Essays (Boston, 1911), 318.

13. Rohde, Herbals, 29, 83, 90, 116, 142–162, 213, 214; Arber, Herbals, 134–138, 174, 176, 233, 237, 284; Mettler, History, 211.

14. Garrison, History, 289.

15. Thomas O. Cockayne, ed., Leechdoms, Wortcunning, and Starcraft of Early England (London, 1864–1866).

16. Jerry Stannard, “Medical Botany,” in Joseph Ewan, ed., A Short History of Botany in the United States (New York, 1969), 147.

17. The idea was also promulgated by N. Culpeper. In the 1661 edition of his Physical Directory, the subtitle is Being an Astrologo-Physical Discourse of the Vulgar Herbs of this Nation: Containing a Compleat Method of Physick, Wliereby a Man May Preserve His Body in Health; or Cure Himself, Being Sick, for Three Pence Charge, with Such Things Only as Crow in England, They Being Most Fit for English Bodies’; see Arber, Herbals, 261.

18. Robert Turner, The British Physician (London, 1664), quoted in Arber, Herbals, 255. This idea was also espoused by Cotton Mather who was convinced that God had placed remedies in each part of the world where they were appropriate; see his Christian Philosopher, 136.

19. Eggleston, Transit, 68–69, 79; Garrison, History, 290.

20. Charles Whitehead, “The Indian Medical Exhibit of the Division of Medicine in the United States National Museum,” Proceedings of the U.S. National Museum, 67, n.d., article 10, 18–19.

21. John B. Beck, Historical Sketch of the State of Medicine in the American Colonies... (Albany, 1850), 35.

22. For information about Indian plant remedies, see “The Herb Spirit Healeth,” Clinical Excerpts, 5, no. 3 (1941), 67–76; Lloyd G. K. Carr, “Interesting Animal Foods, Medicines, and Omens of the Eastern Indians, with Comparison to Ancient European Practices,” Journal of the Washington Academy of Sciences, 44 (1954), 229–235; C. M. Cobb, “Some Medical Practices among the New England Indians and Early Settlers,” Boston Medical and Surgical Journal, 177 (1917), 97–105; William N. Fenton, “Contacts between Iroquois Herbalism and Colonial Medicine,” Annual Report of the Smithsonian Institution, 1941, 503–526; William N. Fenton, “Medicinal Plant Lore of the Iroquois,” New York State University Bulletin to Schools, 35, no. 7 (1949), 233–237; Leaman F. Hallett, “Medicine and Pharmacy of the New England Indians,” Bulletin of the Massachusetts Archaeological Society, 17 (1955), 46–49; John U. Lloyd, Origin and History of All the Pharmacopoeial Vegetable Drugs (Cincinnati, 1929); Henry A. Sigerist, A History of Medicine (New York, 1951), 1; H. W. Youngken, “Drugs of the North American Indians,” American Journal of Pharmacy, 96 (1925), 485–502; 97 (1926), 158–185, 257–271; Beinfield, “New England Doctor,” 99–132; W. T. Bradley, “Medical Practices of the New England Aborigines,” Journal of the American Pharmaceutical Association, 25 (1936), 146; Felter, “Genesis,” 4–64.

23. Bradley, “Practices,” 153.

24. Beinfield, “New England Doctor,” 114.

25. Quoted in Ewan, Short History, 146.

26. Glenn Sonnedecker, Kremers and Urdang’s History of Pharmacy, 4th ed. (Philadelphia, 1976), 152–158.

27. Peter Kalm, Travels into North America, 2nd ed., 2 v. (London, 1772), II, 268.

28. David L. Cowen, “The British North American Colonies as a Source of Drugs” (1966), quoted in Sonnedecker, History of Pharmacy, 152.

29. Felter, “Genesis,” 21.

30. Ibid., 23.

31. Ibid., 57–58.

32. Ibid., 27.

33. Kalm, Travels, i, 160.

34. Ibid., 337–338.

35. Ibid., 155–156.

36. Quoted in Ewan, Short History, 147.

37. Quoted in Beall and Shryock, Cotton Mather, 46.

38. Ibid., 46–47.

39. Ibid., 60.

40. Sonnedecker, History of Pharmacy, 161; Robert B. Austin, Early American Medical Imprints 1668–1820 (1961; rpt. ed., Arlington, Mass., 1977), 98; Francisco Guerra, American Medical Bibliography, 1639–1783 (New York, 1962), 76–77.

41. George Griffenhagen, “Bartholomew Browne, Pharmaceutical Chemist of Salem, Massachusetts, 1698–1704,” Essex Institute Historical Collections, 94 (1961), 19–27.

42. Edward Kremers, “A Drug List of King Philip’s War,” Badger Pharmacist, no. 25 (1939), 1–18.

43. William Salmon, Pharmacopoeia Londinensis (London, 1691), 175.

44. Buckner Hollingsworth, Flower Chronicles (New Brunswick, N.J., 1958), 20; Sonnedecker, History of Pharmacy, 153.

45. Sonnedecker, History of Pharmacy, 153.

46. David L. Cowen, “The Boston Editions of Nicholas Culpeper,” Journal of the History of Medicine and Allied Sciences, XI (1956), 157; Garrison, History, 375.

47. Cowen, “Boston Editions,” 158.

48. Ibid., 165.

49. Sonnedecker, History of Pharmacy, 161.

50. Mettler, History, 216.

51. John C. L. Clark, “The Famous Doctor Stearns,” Proceedings of the American Antiquarian Society, 45, part 1 (1935), 317–324; Guerra, Bibliography, 353, 357, 379, 385, 537, 715, 724, 729; Austin, Imprints, 192.

52. Clark, “Stearns,” 355.

53. Quoted ibid., 327.

54. Quoted ibid., 328.

55. Ibid., 376.

56. Austin, Imprints, 214–215; Guerra, Bibliography, 157–158; John Wesley, Primitive Remedies (rpt. ed., Beverly Hills, Calif., 1973).

57. For information about Cutler, see Brooke Hindle, The Pursuit of Science in Revolutionary America, 1737–1789 (Chapel Hill, N.C., 1956), 303, 313–314, 357; William Parker Cutler and Julia Perkins Cutler, Life, Journals and Correspondence of Rev. Manasseh Cutler. LL.D., 2 v. (Cincinnati, 1888); Ewan, Short History, 36, 38.

58. Cutler and Cutler, Life, I, 73.

59. Ibid., 82.

60. Ewan, Short History, 37; Mettler, History, 211.

61. Hindle, Pursuit, 263–273.

62. Cutler and Cutler, Life, I, 283.

63. Mannasseh Cutler, An Account of Some of the Vegetable Productions Naturally Growing in this Part of America (Boston, 1785), 491.

64. Cutler and Cutler, Life, ii, 259.

65. Ewan, Short History, 6, 37–38, 40, 47–48, 115; Cutler and Cutler, Life, ii, 287–288.

66. Ibid., fn. 291, 289; Ewan, Short History, 41, 89–90; Beall and Shryock, Cotton Mather, 16.

67. Cutler and Cutler, Life, ii, fn., 311–312; Ewan, Short History, 8, 39–40, 47, 115–116, 148.

68. Austin, Imprints, 183; Guerra, Bibliography, 120; Helen Gere Cruickshank, ed., John and William Bartram’s America (New York, 1957), 50–51.

69. Harold W. Rickett, Wild Flowers of the United States: The North Eastern States, 2 v. (New York, 1967), ii, 417.

70. Ewan, Short History, 35.

71. S. A. Green, A History of Medicine in Massachusetts (Boston, 1881), 56; Viets, History, 70.

72. William Douglass, A Summary, Historical and Political, of the First Planting, Progressive Improvements, and Present State of the British Settlements in North America, 2 v. (London, 1755), ii, 216.

73. Douglass, Summary, I, 449.

74. Beck, Historical Sketch, 37–70; Ewan, Short History, 33, 35, 36; John Tennent, “An Epistle to Dr. Mead concerning the Seneca Rattle-snake root,” Edinburgh Medical Essays and Observations, 6 (1743), 376.

75. Jones, Angel of Bethesda, xiv, xxxix.

76. David L. Cowen, “The Edinburgh Pharmacopoeia,” in The Early Years of the Edinburgh Medical School, ed. R. G. W. Anderson and A. D. C. Simpson (Edinburgh, 1976), 25–45.

77. “Letters of Samuel Lee and Samuel Sewall Relating to New England and the Indians,” Publications of the Colonial Society of Massachusetts, 14 (1913), 159; Sonne-decker, History of Pharmacy, 156.

78. Sonnedecker, History of Pharmacy, 172–173; Hindle, Pursuit, 26, 227, 282, 307, 316.

79. Sonnedecker, History of Pharmacy, 172–173.

80. Marion E. Brown, “Adam Kuhn: Eighteenth-Century Physician and Teacher,” Journal of the History of Medicine and Allied Sciences, 5 (1950), 163–177. Also see George E. Gifford, Jr., “Medicine and Natural History: Crosscurrents in Philadelphia in the Nineteenth Century,” Transactions and Studies of the College of Physicians of Philadelphia, 4th ser., 45 (1978), 139–149.

81. George E. GifFord, Jr., “Benjamin Waterhouse the Botanist,” Harvard Medical Alumni Bulletin, 44, no. 2 (Nov./Dec. 1969), 14–16.

82. J. Worth Estes, “Concordance to Dr. Waterhouse’s Hortus Siccus,” in Lloyd E. Hawes, Benjamin Waterhouse, M.D. (Boston, 1974), 17–28.

83. George E. Gifford, Jr., “Physician of Many Facets: Jacob Bigelow,” Harvard Medical Alumni Bulletin, 39, no. 4 (March/April 1965), 34–39. Also see George E. Gifford, Jr., “The Medical Botany of New England, 1782–1842,” Proceedings of the Cambridge Historical Society, 43 (1973–1975), 127–140.

84. See note 11 above.

* After taking his A.B. in Biology at Harvard, Dr. Estes earned an M.A., in Pharmacology, and his M.D. at the Boston University School of Medicine, where he is currently Associate Professor of Pharmacology and Experimental Therapeutics, and of Socio-Medical Sciences (section on the History of Medicine). His publications relevant to this symposium include a chapter on Dr. Matthew Thornton in Physician Signers of the Declaration of Independence (1976) and a book on Hall Jackson and the Purple Foxglove: Medical Practice and Research in Revolutionary America, 1760–1820 (1979).

1. See, for a discussion of one such rare example: Lester S. King, The Medical World of the Eighteenth Century (1958; rpt. ed., Huntington, N.Y., 1971), 310–315.

2. James Thacher, The American New Dispensatory (Boston, 1810).

3. The Kendall coefficient of concordance, W, was calculated as outlined by Siegel (Sidney Siegel, Nonparatnetric Statistics for the Behavioral Sciences [New York, 1956], 229–238). The median number of drugs administered to their patients by each of the four physicians was computed by probit analysis of the cumulated percent of patients treated with increasing numbers of drugs (J. T. Litchfield, Jr., “A Method for Rapid Graphic Solution of Time-Per Cent Effect Curves,” Journal of Pharmacology and Experimental Therapeutics, 97 [1949], 399–408). Life expectancies were calculated by the method of Sachs (Rose Sachs, “Life Table Technique in the Analysis of Response-Time Data from Laboratory Experiments on Animals,” Toxicology and Applied Pharmacology, 1 [1959], 203–227).

4. Frank C. Mevers, ed., Guide to the Microfilm Edition of the Papers ofJosiah Bartlett (1729–1795) (Concord, N.H., 1976), 7–17; Frank C. Mevers, “Josiah Bartlett: Dedicated Physician, Sterling Patriot,” in George E. Gifford, Jr., ed., Physician Signers of the Declaration of Independence (New York, 1976), 99–121. Also see Frank C. Mevers, ed., The Papers of Josiah Bartlett (Hanover, N.H., 1979), which supplements the microfilm edition.

5. D. Hamilton Hurd, History of Rockingham and Strafford Counties, New Hampshire (Philadelphia, 1882), 189; Louis C. Duncan, Medical Men in the American Revolution 1775–1783 (Carlisle Barracks, Penna., 1931), 407.

6. Howard A. Kelly and Walter L. Burrage, Dictionary of American Medical Biography (1928; rpt. ed., Boston, 1971), s.v. “William Aspinwall”; Philip Cash, Medical Men at the Siege of Boston, April 1775 – April 1776 (Philadelphia, 1973), 160.

7. Ibid., 163; Kelly and Burrage, Dictionary, s.v. “David Townsend.”

8. See Douglas Lamar Jones, “Charity, Medical Charity, and Dependency in Eighteenth-Century Essex County, Massachusetts,” above, 199–213.

9. Frank C. Mevers, ed., Microfilm Edition of the Papers of Josiah Bartlett (1729–1795) (Concord, N.H., 1976), frame 3075; J. Worth Estes, “‘As Healthy a Place as Any in America’: Revolutionary Portsmouth, N.H.,” Bulletin of the History of Medicine, 50 (1976), 536–552; Robert V. Wells, The Population of the British Colonies in America before 1776 (Princeton, N.J., 1975), 72, 76.

10. William B. Weeden, Economic and Social History of New England, 2620–1789, 2 v. (Boston, 1890), II, 745–768; Carl Bridenbaugh, Cities in Revolt: Urban Life in America, 2743–1776 (1955; rev. rpt. ed., New York, 1971), 89.

11. Lyman Spalding and Richard Thurston, Bills of Mortality for Portsmouth, New Hampshire (1801–1811, 1818–1820), 14 broadsheets, Boston Medical Library. The Spearman rank difference correlation coefficient shows no similarity between the rankings of monthly morbidity in Kingston from 1751 through 1787 and of monthly mortality in Portsmouth from 1801 through 1820.

12. Wecden, Economic History, ii, 473, 484, 753–759; Bridenbaugh, Cities, 89, 252; Timothy Dwight, Travels in New England and New York, ed. B. M. Solomon & P. M. King, 4 v. (Cambridge, Mass., 1969), I, 301.

13. Ibid., iv, 327.

14. J. Worth Estes, “An Account of the Foxglove in America,” Bulletin of the History of Medicine, 47 (1973), 394–408; Kelly and Burrage, Dictionary, s.v. “William Aspinwall”; James Thacher, American Medical Biography (1828; rpt. ed., New York, 1967), 91–95; Levi Bartlett, “The Memoirs of His Late Excellency Josiah Bartlett First Governor of the State of New-Hampshire,” in Mevers, Microfilm, see note 9, ms 22, frame 5155; Josiah Bartlett to Mary Bartlett, 2 October 1775, Microfilm frame 0190; Josiah Bartlett, “Itineraries,” ms, 28 November 1775, Microfilm frame 3364. Operative details of couching can be found in J. Worth Estes, Hall Jackson and the Purple Foxglove: Medical Practice and Research in Revolutionary America, 1760–1820 (Hanover, N.H., 1979), 6–9.

15. Estes, “As Healthy a Place,” see note 9; J. Potter, “The Growth of Population in America, 1700–1860,” in D. V. Glass and D. E. C. Eversley, eds., Population in History (Chicago, 1965), 638–639.

16. More precisely, Kingston suffered 12.7 ± 7.6 deaths per year, and Kensington 9.1 ± 6.5, during the years of Bartlett’s and Rowe’s practices, respectively. These figures are more directly comparable with those in Table VII.

17. Ernest Caulfield “A History of the Terrible Epidemic, Vulgarly Called the Throat Distemper, as It Occurred in His Majesty’s New England Colonies between 1735 and 1740,” Yale Journal of Biology and Medicine, 11 (1939), 219–272. See also the same author’s paper “Some Common Diseases of Colonial Children” in Publications of the Colonial Society of Massachusetts, 35 (1951), 4–65.

18. The Kendall coefficient of concordance, W, is 0.881, its chi-squared is 66.941, at P < 0.005. Spearman rank difference correlation coefficients result in identical conclusions.

19. Thacher, Dispensatory, see note 2, 330, 366; J. Worth Estes, “John Jones’s Mysteries of Opium Revealed (1701): Key to Historical Opiates,” Journal of the History of Medicine and Allied Sciences, 34 (1979), 200–209. Camphor, still used in liniments and, by mouth, as a carminative, can cause death associated with central nervous system stimulation (Robert Kopelman, Sanford Miller, Raymond Kelly, and Irving Sunshine, “Camphor Intoxication Treated by Resin Hemoperfusion,” Journal of the American Medical Association, 241 [1979], 727–728).

20. Estes, “Foxglove in America.”

21. Pearson product-moment correlation coefficients, r, were calculated to assess the degree of relationship among the four physicians’ uses of the active ingredients listed.

22. r=0.643, P<0.01.

23. r=0.239, P<0.05, and r=0.414, P<0.01, respectively.

24. r=0.072, P>0.05.

25. r=0.615, P<0.01, for Bartlett, and r=0.330, P<0.01, for Townsend.

26. r=o.336, P<0.01.

27. r=0.529.

28. r=0.750.

29. Jeremy Belknap, The History of New-Hampshire, 2nd ed., 3 v. (Boston, 1813), III, 73–94

30. Richard Harrison Shryock, Medicine and Society in America, 1660–1860 (Ithaca, 1962), 24.

31. Bridenbaugh, Cities, see note 10, 199.

32. See, for instance, K. Danner Clouser, “Clinical Medicine as Science: Editorial,” Journal of Medicine and Philosophy, 2 (1977), 1–7; also see other papers in the same issue of that journal.

33. Shryock, Medicine and Society, 51, 66.

34. William Heberden, Commentaries on the History and Cure of Diseases (1802; rpt. ed., New York, 1962), 5–7.

35. James McKittrick Adair, Medical Cautions . . . (London, 1787), 77; Levi Bartlett, “Memoirs,” see note 14, 22–24, frames 5155–5156.

36. [Henry Mellen], poem on title page ofJabez Dow, Bill of Mortality for Kensington, N.H. (Dover, N.H., 1802).

37. King, Medical World, see note 1, 32–44, 56–58, 103, 107, 120; Oxford English Dictionary and American Heritage Dictionary, s.v. “Empiric,” “Empirical,” “Science,” “Scientific.”

38. Sometime between 1800 and 1810 Dr. Jabez Dow (1776–1839) of Dover, New Hampshire, prepared a manuscript outline of the materia medica, probably intending to publish a book on the subject. His classification resembles that used by James Thacher, although their organizations differ, especially as to the subclasses recognized by each. Dow lists the “particular” drugs he thought to be the most efficacious in each class. The drugs recommended by Dow account for about two-thirds of the prescriptions actually administered by Bartlett, Rowe, Aspinwall, and Townsend, and for about eighty percent of the active ingredients employed by them. All together the five physicians were most consonant in the drugs they used the most often. When Thacher’s Dispensatory appeared, Dow was most enthusiastic about both its relevance to the practice of medicine and its tone: “For an American physician this work is in every respect superior to Duncan’s Dispensatory & supersedes the one published some years ago at Philadelphia (Murray’s El. Pharm. & Mat. Med.). . . . [Thacher has treated his subject in a way] calculated to induce a cool & impartial trial of such of these medicines as he may not have been previously acquainted with, which appears to be the only means by which new medicines get into immediate & general use among men of medical Science.” (Jabez Dow, “Materia Medica,” MS in Jabez Dow Papers, Boston Medical Library, 18 pp.: Jabez Dow to Dr. Joseph Burden, Tamworth, N.H., 11 August 1810, in “Manuscript No. 1,” MS Blank book in Jabez Dow Papers, Boston Medical Library, 84; George Wadleigh, Notable Events in the History of Dover, New Hanpshire [Dover, N.H., 1913].)

39. Shryock, Medicine and Society, see note 30, 52.

40. Samuel P. Griffits, J. Morris, John R. B. Rodgers, Caspar Wistar, Jun., William Clarkson, and Michael Leib, [“Return of the Diseases of the Patients of the Philadelphia Dispensary,”] Transactions of the College of Physicians of Philadelphia, 1 (1793), 2–42. Many more such data will be necessary before we can definitively retute the common assumption that historic therapeutic practices were inherently irrational, or even “humbuggery,” as exemplified in Hartwin A. Schulze, “Some Old Bizarre Medical Remedies,” Scientific Monthly, May 1935, 431–439. Comparable data for a military population may be found in Estes, Hall Jackson; see note 14, Table 4.

41. For the derivation of similar conclusions from different kinds of evidence, and for the historical development of the medical profession’s concept of the vis medicatrix naturae in America, see Charles E. Rosenberg, “The Therapeutic Revolution: Medicine, Meaning, and Social Change in Nineteenth-Century America,” Perspectives in Biology and Medicine, 20 (1977), 485–506; John Harley Warner, “‘The Nature-Trusting Heresy’: American Physicians and the Concept of the Healing Power of Nature in the 1850’s and 1860’s,” Perspectives in American History, 11 (1977–1978), 291–324.

42. Belknap, History of New-Hampshire, see note 29, iii, 171–174.

43. Levi Bartlett, “Memoirs,” see note 14, 24, frame 5156.

44. Josiah Bartlett to Benjamin Rush, 25 January 1783, Mevers, Bartlett Microfilm, see note 9, item 1616; Benjamin Rush to Josiah Bartlett, 23 February 1783, ibid., item 0634.

45. Levi Bartlett, “Memoirs,” see note 14, 25, frame 5156.

* Sources of the definitions: James Thacher, The American New Dispensatory (Boston, 1810); A. C. Wootton, Chronicles of Pharmacy, 2 v. in 1 (1910; rpt. ed., Boston, 1971); Louis S. Goodman and Alfred Gilman, The Pharmacological Basis of Therapeutics, 5th ed. (New York, 1975); Walter H. Lewis and Memory P. F. Elvin-Lewis, Medical Botany (New York, 1977); The Merck Index, 7th ed. (Rahway, N.J., 1960); American Heritage Dictionary; Oxford English Dictionary; John Woodall, The Surgions Mate (London, 1617); W. Lewis, The New Dispensatory (Edinburgh and London, 1786); J. Worth Estes, “John Jones’s Mysteries of Opium Reveal’d (1701): Key to Historical Opiates,” Journal of the History of Medicine and Allied Sciences, 34 (1979), 200–209. Unless a specific reference is included in the entry, modern information about a drug’s special pharmacological and toxicological properties can usually be found in standard texts, like that of Goodman and Gilman cited just above, unless no such information is readily available.

Botanic Remedies in Colonial Massachusetts, 1620–1820*

Botanic Remedies in Colonial Massachusetts, 1620–1820 *